Professor Alexander Yakunin

Professor In Enzyme Discovery and Application

Contact info

 

Professor Alexander Yakunin (Iakounine)

 

Office: Thoday Building, room S25

Email: a.iakounine@bangor.ac.uk

Tel: 01248 388399

 

Research focus: enzyme discovery, enzymology, enzyme applications

  1. Article › Research › Peer-reviewed
  2. A family of metal-dependent phosphatases implicated in metabolite damage-control

    Huang, L., Khusnutdinova, A., Nocek, B., Brown, G., Xu, X., Cui, H., Petit, P., Flick, R., Zallot, R., Balmant, K., Ziemak, M. J., Shanklin, J., de Crecy-Lagard, V., Fiehn, O., Gregory, J. F. . III., Joachimiak, A., Savchenko, A., Yakunin, A. F. & Hanson, A. D., Aug 2016, In: Nature Chemical Biology. 12, 8, p. 621-627

    Research output: Contribution to journalArticlepeer-review

  3. Published

    A microplate screen to estimate metal-binding affinities of metalloproteins

    Diep, P., Mahadevan, R. & Yakunin, A. F., 15 Nov 2020, In: Analytical biochemistry. 609, p. 113836

    Research output: Contribution to journalArticlepeer-review

  4. Published

    Activity screening of environmental metagenomic libraries reveals novel carboxylesterase families

    Popovic, A., Hai, T., Tchigvintsev, A., Hajighasemi, M., Nocek, B., Khusnutdinova, A. N., Brown, G., Glinos, J., Flick, R., Skarina, T., Chernikova, T., Yim, V., Bruls, T., Le Paslier, D., Yakimov, M. M., Joachimiak, A., Ferrer, M., Golyshina, O., Savchenko, A., Golyshin, P. & Yakunin, A. F., Mar 2017, In: Scientific Reports. 7, 44103, 44103.

    Research output: Contribution to journalArticlepeer-review

  5. Alkene hydrogenation activity of enoate reductases for an environmentally benign biosynthesis of adipic acid

    Joo, J. C., Khusnutdinova, A. N., Flick, R., Kim, T., Bornscheuer, U. T., Yakunin, A. F. & Mahadevan, R., 1 Feb 2017, In: Chemical Science. 8, 2, p. 1406-1413

    Research output: Contribution to journalArticlepeer-review

  6. Published

    Biochemical and structural insights into enzymatic depolymerization of polylactic acid and other polyesters by microbial carboxylesterases

    Hajighasemi, M., Nocek, B. P., Tchigvintsev, A., Brown, G., Flick, R., Xu, X., Cui, H., Hai, T., Joachimiak, A., Golyshin, P., Savchenko, A., Edwards, E. A. & Yakunin, A. F., 18 Apr 2016, In: Biomacromolecules. 17, 6, p. 2027-2039

    Research output: Contribution to journalArticlepeer-review

  7. Biosynthesis and activity of prenylated FMN cofactors

    Wang, P-H., Khusnutdinova, A. N., Luo, F., Xiao, J., Nemr, K., Flick, R., Brown, G., Mahadevan, R., Edwards, E. & Yakunin, A., 17 May 2018, In: Cell Chemical Biology. 25, 5, p. 560-570

    Research output: Contribution to journalArticlepeer-review

  8. CRISPR RNA binding and DNA target recognition by purified Cascade complexes from Escherichia coli

    Beloglazova, N., Kuznedelov, K., Flick, R., Datsenko, K. A., Brown, G., Popovic, A., Lemak, S., Semenova, E., Severinov, K. & Yakunin, A. F., Jan 2015, In: Nucleic Acids Research. 43, 1, p. 530-543

    Research output: Contribution to journalArticlepeer-review

  9. Published

    CRISPR-induced DNA reorganization for multiplexed nucleic acid detection

    Karlikow, M., Amalfitano, E., Yang, X., Doucet, J., Chapman, A., Sadat-Moussavi, P., Homme, P., Sutyrina, P., Chang, W., Lemak, S., Yakunin, A., Dolezal, A. G., Kelley, S., Foster, L., Harpur, B. & Pardee, K., 17 Mar 2023, In: Nature Communications. 14, 1, 1505.

    Research output: Contribution to journalArticlepeer-review

  10. Published

    Determinants and prediction of esterase substrate promiscuity patterns

    Martínez-Martínez, M., Coscolín, C., Santiago, G., Chow, J., Stogios, P. J., Bargiela, R., Gertler, C., Navarro-Fernández, J., Bollinger, A., Thies, S., Méndez-García, C., Popovic, A., Brown, G., Chernikova, T., García-Moyano, A., Bjerga, G. E. K., Perez-Garcia, P., Hai, T., del Pozo, M. V., Stokke, R., Steen, I. H., Cui, H., Xu, X., Nocek, B., Alcaide, M., Disasto, M., Mesa, V., Pelaez, A. I., Sanchez, J., Buchholz, P. C. F., Pleiss, J., Fernández-Guerra, A., Glockner, F. O., Golyshina, O., Yakimov, M. M., Savchenko, A., Jaeger, K-E., Yakunin, A. F., Streit, W. R., Golyshin, P., Guallar, V. & Ferrer, M., 2018, In: ACS Chemical Biology. 13, 1, p. 225-234

    Research output: Contribution to journalArticlepeer-review

  11. Published

    Diversity of hydrolases from hydrothermal vent sediments of the Levante Bay, Vulcano Island (Aeolian archipelago) identified by activity-based metagenomics and biochemical characterization of new esterases and an arabinopyranosidase

    Placido, A., Hai, T., Ferrer, M., Chernikova, T. N., Distaso, M. A., Armstrong, D., Yakunin, A. F., Toshchakov, S. V., Yakimov, M. M., Kublanov, I. V., Golyshina, O., Pesole, G., Ceci, L. R. & Golyshin, P., 1 Dec 2015, In: Applied Microbiology and Biotechnology. 99, 23, p. 10031-10046

    Research output: Contribution to journalArticlepeer-review

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