Dyfrig Hughes - Research outputs

Published

Follow-up of cancer in primary care versus secondary care: systematic review

Lewis, R. A., Neal, R. D., Williams, N. H., France, B., Hendry, M., Russell, D., Hughes, D. A., Russell, I., Stuart, N. S. A., Weller, D. & Wilkinson, C., 1 Jul 2009, In: British Journal of General Practice. 59, 564, p. e234-e247

Research output: Contribution to journal › Article › peer-review

Published

Patients' and healthcare professionals' views of cancer follow-up: systematic review

Lewis, R., Neal, R. D., Hendry, M., France, B., Williams, N. H., Russell, D., Hughes, D. A., Russell, I., Stuart, N. S. A., Weller, D. & Wilkinson, C., Jul 2009, In: British Journal of General Practice. 59, 564, p. e248-e259

Research output: Contribution to journal › Article › peer-review

Published

Decision analytic modelling methods for the assessing the effectiveness of treatment sequences for clinical and economic decision making: a methodological review

Lewis, R., Hughes, D. & Wilkinson, C., 30 Nov 2017, In: Value in Health. 20, 9, p. A748 1 p.

Research output: Contribution to journal › Article › peer-review

Published

Quantitative evidence synthesis methods for the assessment of the effectiveness of treatment sequences for clinical and economic decision-making: a review and taxonomy of simplifying assumptions

Lewis, R., Hughes, D., Sutton, AJ. & Wilkinson, C., Jan 2021, In: PharmacoEconomics. 39, 1, p. 25-61 37 p.

Research output: Contribution to journal › Article › peer-review

Published

Nurse-led vs. conventional physician-led follow-up for patients with cancer: systematic review

Lewis, R., Neal, R. D., Williams, N. H., France, B., Wilkinson, C. E., Hendry, M., Russell, D., Russell, I., Hughes, D., Stuart, N. S. & Weller, D., 1 Apr 2009, In: Journal of Advanced Nursing. 65, 4, p. 706-723

Research output: Contribution to journal › Article › peer-review

Published

A “Bundle of Care” to Improve Anticoagulation Control in Patients Receiving Warfarin in Uganda and South Africa: Protocol for an Implementation Study

Jorgensen, AL., Waitt, C., Orrell, C., Cheng-Hock, T., Sekaggya-Wiltshire, C., Hughes, D., Allen, E., Okello, E., Tatz, G., Culeddu, G., Asiimwe, I. G., Semakula, J. R., Mouton, J. P., Cohen, K., Blockman, M., Lamorde, M. & Pirmohamed, M., 19 Jul 2023, In: Journal of Medical Internet Research. 12, e46710.

Research output: Contribution to journal › Article › peer-review

Published

Mechanistically informed non-invasive peripheral nerve stimulation for peripheral neuropathic pain: a randomised double-blind sham-controlled trial

Johnson, S., Marshall, A., Hughes, D., Holmes, E., Henrich, F., Nurmikko, T., Sharma, M., Frank, B., Bassett, P., Marshall, A. & Goebel, A., 6 Nov 2021, In: Journal of Translational Medicine. 19, 1, 458.

Research output: Contribution to journal › Article › peer-review

Published

A randomised, patient-assessor blinded, sham-controlled trial of external noninvasive peripheral nerve stimulation for chronic neuropathic pain following peripheral nerve injury (EN-PENS trial): study protocol for a randomised controlled trial

Johnson, S., Goebel, A., Richey, R., Holmes, E. & Hughes, D., 6 Dec 2016, In: Trials. 17, 574.

Research output: Contribution to journal › Article › peer-review

Published

Evidence to support inclusion of pharmacogenetic biomarkers in randomised controlled trials

Johnson, D., Jorgensen, A., Hughes, D. & Pirmohamed, M., 1 Sept 2019, In: Journal of Personalized Medicine. 9, 3, 19 p., 42.

Research output: Contribution to journal › Review article › peer-review

Published

Letter to the Editor. Phase III randomized controlled trials are essential to properly evaluate the role of radiotherapy in WHO grade II meningioma

Jenkinson, M., Weber, D., Haylock, B., Sherratt, F., Young, B., Weller, M., Bulbeck, H., Culeddu, G., Hughes, D., Brain, A., Das, K., Preusser, M., Francis, P. & Gamble, C., 17 Aug 2018, In: Journal of Neurology, Neurosurgery and Psychiatry.

Research output: Contribution to journal › Letter › peer-review

Published

The ROAM/EORTC-1308 trial: Radiation versus Observation following surgical resection of Atypical Meningioma: study protocol for a randomised controlled trial

Jenkinson, M. D., Javadpour, M., Haylock, B. J., Young, B., Gillard, H., Vinten, J., Bulbeck, H., Das, K., Farrell, M., Looby, S., Hickey, H., Preusser, M., Mallucci, C. L., Hughes, D., Gamble, C. & Weber, D. C., 14 Nov 2015, In: Trials. 16

Research output: Contribution to journal › Article › peer-review

Published

Impact of relaxing Covid-19 social distancing measures on rural North Wales: a simulation analysis

Hughes, R. P. & Hughes, D., 14 Dec 2020, In: Frontiers in Public Health. 8, 562473.

Research output: Contribution to journal › Article › peer-review

Published

Cost-effectiveness analysis of adalimumab for the treatment of uveitis associated with Juvenile Idiopathic Arthritis

Hughes, D. A., Culeddu, G., Plumpton, C. O., Wood, E., Dick, A. D., Jones, A. P., McKay, A., Williamson, P. R., Compeyrot Lacassagne, S., Hardwick, B., Hickey, H., Woo, P., Beresford, M. W. & Ramanan, A. V., Mar 2019, In: Ophthalmology. 126, 3, p. 415-424

Research output: Contribution to journal › Article › peer-review

Published

Cost-effectiveness analysis of adalimumab for the treatment of uveitis associated with Juvenile Idiopathic Arthritis: Authors’ reply.

Hughes, D., Culeddu, G., Plumpton, C., Wood, E., Dick, A. D., Beresford, M. W. & Ramanan, A. V., Mar 2019, In: Ophthalmology. 126, 3, p. e24-e25

Research output: Contribution to journal › Letter › peer-review

Published

Health utilities and costs for neuromyelitis optica spectrum disorder

Hughes, D., Bourke, S., Jones, A., Bhatt, R., Huda, S., Mutch, K. & Jacob, A., 2022, In: Orphanet Journal of Rare Diseases. 17, 11 p., 159.

Research output: Contribution to journal › Article › peer-review

Published

Profitability and Market Value of Orphan Drug Companies: A Retrospective, Propensity-Matched Case-Control Study

Hughes, D. & Poletti-Hughes, J., 21 Oct 2016, In: PLoS ONE. 11, 10, e0164681.

Research output: Contribution to journal › Article › peer-review

Published

Economics of pharmacogenetic guided treatments: Underwhelming or overstated?

Hughes, D., May 2018, In: Clinical Pharmacology and Therapeutics. 103, 5, p. 749-751

Research output: Contribution to journal › Article › peer-review

Published

Rare disease prevention and treatment: The need for a level playing field

Hughes, D. & Plumpton, C., Feb 2018, In: Pharmacogenomics. 19, 3, p. 243-247

Research output: Contribution to journal › Article › peer-review

Published

Acute chloroquine poisoning: A comprehensive experimental toxicology assessment of the role of diazepam

Hughes, D., Nov 2020, In: British Journal of Pharmacology. 177, 21, p. 4975-4989 15 p.

Research output: Contribution to journal › Article › peer-review

Published

Management of Patients Symptomatically Unresponsive to Levothyroxine: Natural Desiccated Thyroid Extract or the Combination of Levothyroxine and Liothyronine? A Research Priority

Hughes, D., Livingston, M. & Heald, A., Sept 2020, In: Experimental and Clinical Endocrinology & Diabetes . 128, 9, p. 596-598

Research output: Contribution to journal › Letter › peer-review

Published

Liothyronine for hypothyroidism: A candidate for disinvestment or in need of further research? A value of information analysis

Hughes, D., Skiadas, K., Fitzsimmons, D., Anderson, P. & Heald, A., 3 Dec 2021, In: BMJ Open. 11, 12, e051702.

Research output: Contribution to journal › Article › peer-review

Published

Medication adherence – key considerations for clinical pharmacologists

Hughes, D., Apr 2020, In: British Journal of Clinical Pharmacology. 86, 4, p. 628-629 2 p.

Research output: Contribution to journal › Editorial › peer-review

E-pub ahead of print

We need to talk about values: a proposed framework for the articulation of normative reasoning in health technology assessment

Hughes, D., 27 Sept 2023, (E-pub ahead of print) In: Health Economics, Policy and Law.

Research output: Contribution to journal › Article › peer-review

Published

Medicines Shortages in the United Kingdom

Hughes, D., Oct 2019, In: Clinical Pharmacology and Therapeutics. 106, 4, p. 712

Research output: Contribution to journal › Letter › peer-review

Published

Mechanism-Based Approach to the Economic Evaluation of Pharmaceuticals: Pharmacokinetic/Pharmacodynamic/Pharmacoeconomic Analysis of Rituximab for Follicular Lymphoma.

Hughes, D., Pink, J., Lane, S. & Hughes, D. A., 19 Mar 2012, In: Pharmacoeconomics.

Research output: Contribution to journal › Article › peer-review

Published

All Wales Medicines Strategy Group Final Appraisal Report - Fondaparinux Sodium (Arixtra®) for UA/NSTEMI.

Hughes, D., Hughes, D. A. & All Wales Strategy Group., N. V., 1 Jan 2008, 2008 ed. Unknown.

Research output: Book/Report › Commissioned report

Published

Biosimilars: Evidential standards for health technology assessment.

Hughes, D. & Hughes, D. A., 1 Mar 2010, In: Clinical Pharmacology and Therapeutics. 87, 3, p. 257-261

Research output: Contribution to journal › Article › peer-review

Published

All Wales Medicines Strategy Group Final Appraisal Report - Atazanavir (Reyataz) in treatment-naïve patients.

Hughes, D., Hughes, D. A. & All Wales Strategy Group., N. V., 1 Jan 2008, 2008 ed. Unknown.

Research output: Book/Report › Commissioned report

Published

Pharmacoeconomics appraisals by the all Wales medicines strategy group

Hughes, D. & Hughes, D. A., 1 Jul 2004.

Research output: Contribution to conference › Paper

Published

Genetic and environmental factors determining clinical outcomes and cost of warfarin therapy: a prospective study.

Hughes, D., Jorgensen, A. L., Al-Zubiedi, S., Zhang, J. E., Keniry, A., Hanson, A., Hughes, D. A., Van Eker, D., Stevens, L., Hawkins, K., Toh, C. H., Kamali, F., Daly, A. K., Fitzmaurice, D., Coffey, A., Williamson, P. R., Park, B. K., Deloukas, P. & Pirmohamed, M., 1 Oct 2009, In: Pharmacogenetics and Genomics. 19, 10, p. 800-812

Research output: Contribution to journal › Article › peer-review

Published

The development of a QALY measure for epilepsy: NEWQOL-6D

Hughes, D., Mulhern, B., Rowen, D., Jacoby, A., Marson, T., Snape, D., Hughes, D. A., Latimer, N., Baker, G. A. & Brazier, J. E., 1 May 2012, In: Epilepsy and Behavior. 24, 1, p. 36-43

Research output: Contribution to journal › Article › peer-review

Published

Impact of pharmacogenetics on the costs of managing adverse events with warfarin: A prospective analysis.

Hughes, D., Hughes, D. A., Al-Zubiedi, S., Hanson, A., Jorgensen, A. & Pirmohamed, M., 1 Jan 2009.

Research output: Contribution to conference › Paper

Published

Defining rewardable innovation in drug therapy

Hughes, D., Aronson, J. K., Ferner, R. E. & Hughes, D. A., 1 Apr 2012, In: Nature Reviews Drug Discovery. 11, p. 253-254

Research output: Contribution to journal › Article › peer-review

Published

Statistical comments are unfounded.

Hughes, D., Hughes, D. A., Cowell, W., Koncz, T. & Cramer, J., 1 Mar 2008, In: Value in Health. 11, 2, p. 346

Research output: Contribution to journal › Article › peer-review

Published

The impact of non-compliance on the cost-effectiveness of pharmaceuticals: A review of the literature.

Hughes, D., Hughes, D. A., Bagust, A., Haycox, A. & Walley, T., 1 Oct 2001, In: Health Economics. 10, 7, p. 601-615

Research output: Contribution to journal › Article › peer-review

Published

A single centre open phase IV study to evaluate the safety and tolerability of chlorproguanil-dapsone when dosed by defined height bands

Hughes, D., Makanga, M., Winstanley, P. & Hughes, D. A., 1 Nov 2004.

Research output: Contribution to conference › Paper

Published

Welsh Health Economics Network (WHEN): Scoping Report.

Hughes, D., Farr, A., O Ceilleachair, A., Cohen, D., Hughes, D. A. & Phillips, C., 1 Jan 2005, 2005 ed. Unknown.

Research output: Book/Report › Commissioned report

Published

Estimating Drug Costs in Economic Evaluations in Ireland and the UK: An Analysis of Practice and Research Recommendations.

Hughes, D., Hughes, D. A., Tilson, L. & Drummond, M. F., 1 May 2009, In: Pharmacoeconomics. 27, 8, p. 635-643

Research output: Contribution to journal › Article › peer-review

Published

Orphan drug treatments: economic considerations

Hughes, D. & Hughes, D. A., 1 Nov 2007.

Research output: Contribution to conference › Paper

Published

Clinical Pharmacology: Special safety considerations in drug development and pharmacovigilance.

Hughes, D., Atuah, K. N., Hughes, D. A. & Pirmohamed, M., 1 Jan 2004, In: Drug Safety. 27, 8, p. 535-554

Research output: Contribution to journal › Article › peer-review

Published

Current assessment of risk-benefit by regulators: is it time to introduce decision analyses?

Hughes, D., Hughes, D. A., Bayoumi, A. M. & Pirmohamed, M., 1 Aug 2007, In: Clinical Pharmacology and Therapeutics. 82, 2, p. 123-127

Research output: Contribution to journal › Article › peer-review

Published

Quantitative risk-benefit analysis

Hughes, D. & Hughes, D. A., 1 May 2007.

Research output: Contribution to conference › Paper

Published

Impact of the abolition of the prescription charge in Wales.

Hughes, D., Hughes, D. A., Alam, M. F., Cohen, D., Dunstan, F., Groves, S. & Routledge, P., 1 Jan 2009, p. O41.

Research output: Contribution to conference › Paper

Published

Ultra-long acting pharmaceuticals: Do they result in better outcomes, and at an acceptable cost?

Hughes, D. & Hughes, D. A., 1 Nov 2006.

Research output: Contribution to conference › Paper

Published

All Wales Medicines Strategy Group Final Appraisal Report - Emtricitabine/tenofovir DF (Truvada)

Hughes, D., Hughes, D. A. & All Wales Strategy Group., N. V., 1 Jan 2007, 2007 ed. Unknown.

Research output: Book/Report › Commissioned report

Published

Pharmacoeconomic models that incorporate non-compliance

Hughes, D. & Hughes, D. A., 1 Jul 2004.

Research output: Contribution to conference › Paper

Published

All Wales Medicines Strategy Group Final Appraisal Report - Icatibant (Firazyr) for symptomatic treatment of acute attacks of hereditary angioedema (HAE) in adults (with C1-esterase-inhibitor deficiency).

Hughes, D., Hughes, D. A. & All Wales Strategy Group., N. V., 1 Jan 2008, 2008 ed. Unknown.

Research output: Book/Report › Commissioned report

Published

The future challenges

Hughes, D., Hughes, D. A., Walley, T. (ed.), Haycox, A. (ed.), Boland, A. (ed.) & Breckenridge, A. (ed.), 1 Jan 2004, Pharmacoeconomics. 2004 ed. Adis International, p. 167-174

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Published

The pharmacokinetic profile of Warfarn: a systematic review

Hughes, D., Al-Zubiedi S.*, N. V., Hughes D.A., N. V. & Pirmohamed, M., 1 Dec 2007.

Research output: Contribution to conference › Paper

Published

Warfarin pharmacogenetics: Economic considerations.

Hughes, D., Hughes, D. A. & Pirmohamed, M., 1 Jan 2007, In: Pharmacoeconomics. 25, 11, p. 899-902

Research output: Contribution to journal › Article › peer-review

Published

Public funding of drugs for orphan diseases

Hughes, D. & Hughes, D. A., 1 Nov 2005.

Research output: Contribution to conference › Paper

Published

Pharmacokinetic-Pharmacodynamic modelling of Lapdap (CPG-DDS) combination.

Hughes, D., Hughes, D. A., Watkins, B. & Winstanley, P., 1 Jan 2001, 2001 ed. Unknown.

Research output: Book/Report › Commissioned report

Published

Multiple imputation of multiple multi-item scales when a full imputation model is infeasible

Hughes, D., Plumpton, C. O., Morris, T., Hughes, D. A. & White, I. R., 26 Jan 2016, In: BMC Research Notes. 9, 45, p. 1-15

Research output: Contribution to journal › Article › peer-review

Published

Integrating compliance and persistence in health economics models

Hughes, D. & Hughes, D. A., 1 Jan 2008.

Research output: Contribution to conference › Paper

Published

All Wales Medicines Strategy Group Final Appraisal Report - Abacavir 600mg/lamivudine 300mg (Kivexa) in antiretroviral combination therapy for the treatment of Human Immunodeficiency Virus infection in adults and adolescents from 12 years of age.

Hughes, D., Hughes, D. A. & All Wales Strategy Group., N. V., 1 Jan 2008, 2008 ed. Unknown.

Research output: Book/Report › Commissioned report

Published

Engaging with the MRC Methodology Hubs – NWHTMR.

Hughes, D. & Hughes, D. A., 1 Jan 2009.

Research output: Contribution to conference › Paper

Published

Investigating factors influencing user choices to visit either general practitioners or community pharmacists in the management of minor ailments - piloting a discrete choice experiment

Hughes, D., Myles, S., Hughes, D. A., Longo, M. & Lisles, C., 1 Jun 2006.

Research output: Contribution to conference › Paper

Published

Impact of the abolition of the prescription charge in Wales.

Hughes, D., Hughes, D. A., Alam, M. F., Cohen, D., Dunstan, F., Groves, S. & Routledge, P., 1 Jan 2009.

Research output: Contribution to conference › Paper

Published

Economic impact of poor compliance with pharmaceuticals.

Hughes, D. & Hughes, D. A., 1 Aug 2002, In: Expert Review of Pharmacoeconomics and Outcomes Research. 2, 4, p. 327-335

Research output: Contribution to journal › Article › peer-review

Published

All Wales Medicines Strategy Group Final Appraisal Report - Fondaparinux Sodium (Arixtra®) for STEMI.

Hughes, D., Hughes, D. A. & All Wales Strategy Group., N. V., 1 Jan 2008, 2008 ed. Unknown.

Research output: Book/Report › Commissioned report

Published

Evaluation of a consultant audit and feedback programme to improve the quality of antimicrobial prescribing in acute medical admissions

Hughes, D., Roberts, E., Dawoud, D. M., Hughes, D. A. & Cefai, C., 1 Oct 2015, In: International Journal of Pharmacy Practice. 23, 5, p. 333-339

Research output: Contribution to journal › Article › peer-review

Published

Development of an economic model to evaluate the cost-effectiveness of rival therapies for treating Crohn’s disease.

Hughes, D., Kikuchi, T., Bodger, K. & Hughes, D. A., 1 Jan 2008, 2008 ed. Unknown.

Research output: Book/Report › Commissioned report

Published

Eliciting patients' preferences using a discrete choice experiment questionnaire: the role played by qualitative data in questionnaire design

Hughes, D., Longo, M., Hughes, D. A., Myles, S. & Lisles, C., 1 Mar 2006.

Research output: Contribution to conference › Paper

Published

Improving Outcomes in Children and Young People with Cancer: Analysis of the Potential Economic Impact of the Guidance.

Hughes, D., Linck, P., Tunnage, B., Hughes, D. A. & Edwards, R. T., 1 Jan 2005, 2005 ed. Unknown.

Research output: Book/Report › Commissioned report

Published

Biosimilars: Evidential standards for health technology assessment.

Hughes, D. & Hughes, D. A., 1 Jan 2009.

Research output: Contribution to conference › Paper

Published

Public meetings of the NICE appraisals committee

Hughes, D. & Hughes, D. A., 1 Dec 2007.

Research output: Contribution to conference › Paper

Published

Impact of non-compliance on the cost-effectiveness of statin therapy

Hughes, D., Hughes, D. A. & Bagust, A., 1 Sept 2001, In: Value in Health. 4, 6, p. 489

Research output: Contribution to journal › Article › peer-review

Published

Use of PK-PD modelling to predict the impact of non-compliance

Hughes, D. & Hughes, D. A., 1 Nov 2003.

Research output: Contribution to conference › Paper

Published

Dabigatran etexilate versus warfarin in management of non-valvular atrial fibrillation in UK context: quantitative benefit-harm and economic analyses

Hughes, D., Pink, J., Lane, S., Pirmohamed, M. & Hughes D.A., N. V., 31 Oct 2011, In: British Medical Journal. 343, p. 1-14

Research output: Contribution to journal › Article › peer-review

Published

All Wales Medicines Strategy Group Final Assessment Report – Agalsidase alfa (Replagal)

Hughes, D., Hughes, D. A. & All Wales Strategy Group., N. V., 1 Jan 2007, 2007 ed. Unknown.

Research output: Book/Report › Commissioned report

Published

A randomised controlled trial of the clinical effectiveness, safety and cost-effectiveness of adalimumab in combination with methotrexate for the treatment of juvenile idiopathic arthritis associated uveitis (SYCAMORE Trial)

Hughes, D., Ramanan, A., Dick, A. D., Benton, D., Compeyrot-Lacassagne, S., Dawoud, D., Hardwick, B., Hickey, H., Hughes, D. A., Jones, A., Woo, P., Edelsten, C., Beresford, M. W. & The SYCAMORE Trail Management Group, N. V., 9 Jan 2014, In: Trials. 15, 14

Research output: Contribution to journal › Article › peer-review

Published

The problem of orphan drugs

Hughes, D., Ferner, R. E. & Hughes, D. A., 16 Nov 2010, In: British Medical Journal. 341, p. 335-341

Research output: Contribution to journal › Article › peer-review

Published

Back to basics: what is the relationship between dose and duration of drug action?

Hughes, D. & Hughes, D. A., 1 May 2006.

Research output: Contribution to conference › Paper

Published

All Wales Medicines Strategy Group Final Appraisal Report – Dasatinib (Sprycel®) Chronic, accelerated or blast phase CML.

Hughes, D., Hughes, D. A. & All Wales Strategy Group., N. V., 1 Jan 2007, 2007 ed. Unknown.

Research output: Book/Report › Commissioned report

Published

The economics of evergreening.

Hughes, D. & Hughes, D. A., 1 Jan 2009.

Research output: Contribution to conference › Paper

Published

Cost-effectiveness analysis of HLA B*5701 genotyping in preventing abacavir hypersensitivity

Hughes, D., Hughes, D. A., Vilar, F. J., Ward, C. C., Alfirevic, A., Park, B. K. & Pirmohamed, M., 1 Jun 2004, In: Pharmacogenetics. 14, 6, p. 335-342

Research output: Contribution to journal › Article › peer-review

Published

Drugs for exceptionally rare diseases: do they deserve special status for funding?

Hughes, D., Tunnage, B. & Yeo, S. T., 1 Nov 2005, In: QJM - An International Journal of Medicine. 98, 11, p. 829-836

Research output: Contribution to journal › Article › peer-review

Published

Is exercise effective in promoting mental well-being in older age? A systematic review.

Hughes, D., Linck, P. G., Windle, G., Hughes, D. A., Linck, P., Russell, I. T. & Woods, R. T., 1 Aug 2010, In: Aging and Mental Health. 14, 6, p. 652-669

Research output: Contribution to journal › Article › peer-review

Published

Cost–effectiveness of pharmacogenetics in anticoagulation: international differences in healthcare systems and costs

Hughes, D., Verhof, T. I., Redekop, W. K., van Schie, R. M., Bayat, S., Daly, A. K., Geitona, M., Haschke-Becher, E., Hughes, D. A., Kamali, F., Levin, L. A., Manolopoulos, V. G., Pirmohamed, M., Siebert, U., Stingl, J. C., Wadelius, M., de Boer, A. & Maitland-van der Zee, A. H., 1 Sept 2012, In: Pharmacogenomics. 13, 12, p. 1405-1417

Research output: Contribution to journal › Article › peer-review

Published