Dr Edgar Hartsuiker

Senior Lecturer in Biomedical Sciences (Cancer Biology)

  1. Article › Research › Peer-reviewed
  2. A 160-bp palindrome is a Rad50.Rad32-dependent mitotic recombination hotspot in Schizosaccharomyces pombe

    Farah, J. A., Hartsuiker, E., Mizuno, K., Ohta, K. & Smith, G. R., May 2002, In: Genetics. 161, 1, p. 461-8 8 p.

    Research output: Contribution to journalArticlepeer-review

  3. A simple Cre-loxP method for chromosomal N-terminal tagging of essential and non-essential Schizosaccharomyces pombe genes

    Werler, P. J. H., Hartsuiker, E. & Carr, A. M., 30 Jan 2003, In: Gene. 304, p. 133-41 9 p.

    Research output: Contribution to journalArticlepeer-review

  4. A single unbranched S-phase DNA damage and replication fork blockage checkpoint pathway

    Marchetti, M. A., Kumar, S., Hartsuiker, E., Maftahi, M., Carr, A. M., Freyer, G. A., Burhans, W. C. & Huberman, J. A., 28 May 2002, In: Proceedings of the National Academy of Sciences of the United States of America. 99, 11, p. 7472-7 6 p.

    Research output: Contribution to journalArticlepeer-review

  5. Published

    A supramodular FHA/BRCT-Repeat architecture mediates Nbs1 adaptor function in response to DNA damage.

    Lloyd, J., Chapman, J. R., Clapperton, J. A., Haire, L. F., Hartsuiker, E., Li, J., Carr, A. M., Jackson, S. P. & Smerdon, S. J., 2 Oct 2009, In: Cell. 139, 1, p. 100-111

    Research output: Contribution to journalArticlepeer-review

  6. Published

    Collaborative Action of Brca1 and CtIP in Elimination of Covalent Modifications from Double-Strand Breaks to Facilitate Subsequent Break Repair

    Nakamura, K., Kogame, T., Oshiumi, H., Shinohara, A., Sumitomo, Y., Agama, K., Pommier, Y., Tsutsui, K. M., Tsutsui, K., Hartsuiker, E., Ogi, T., Takeda, S. & Taniguchi, Y., 22 Jan 2010, In: PLOS Genetics. 6, 1

    Research output: Contribution to journalArticlepeer-review

  7. Ctp1CtIP and Rad32Mre11 nuclease activity are required for Rec12Spo11 removal, but Rec12Spo11 removal is dispensable for other MRN-dependent meiotic functions

    Hartsuiker, E., Mizuno, K., Molnar, M., Kohli, J., Ohta, K. & Carr, A. M., Apr 2009, In: Molecular and Cellular Biology. 29, 7, p. 1671-1681 11 p.

    Research output: Contribution to journalArticlepeer-review

  8. Published

    Data presenting the synthesis of three novel stimuli responsive hyperbranched polymers synthesised via RAFT polymerisation and the bio conjugation of folic acid

    Blackburn, C., Tai, H., Salerno, M., Wang, X., Senan, C., Ratcliffe, I., Hartsuiker, E. & Wang, W., Feb 2020, In: Data in Brief. 28, 104861.

    Research output: Contribution to journalArticlepeer-review

  9. Published

    Deoxynucleoside Salvage in Fission Yeast Allows Rescue of Ribonucleotide Reductase Deficiency but Not Spd1-Mediated Inhibition of Replication

    Fleck, O., Fahnøe, U., Løvschal, K. V., Gasasira Uwamahoro, M-F., Marinova, I. N., Kragelund, B. B., Carr, A. M., Hartsuiker, E., Holmberg, C. & Nielsen, O., 25 Apr 2017, In: Genes. 8, 5, 14 p., 128.

    Research output: Contribution to journalArticlepeer-review

  10. Published

    Distinct Requirements for the Rad32Mre11 Nuclease and Ctp1CtIP in the Removal of Covalently Bound Topoisomerase I and II from DNA

    Hartsuiker, E., Neale, M. J. & Carr, A. M., 16 Jan 2009, In: Molecular Cell. 33, 1, p. 117-123

    Research output: Contribution to journalArticlepeer-review

  11. Double-strand break repair and homologous recombination in Schizosaccharomyces pombe

    Raji, H. & Hartsuiker, E., 15 Oct 2006, In: Yeast. 23, 13, p. 963-76 14 p.

    Research output: Contribution to journalArticlepeer-review

  12. Fission yeast Rad50 stimulates sister chromatid recombination and links cohesion with repair

    Hartsuiker, E., Vaessen, E., Carr, A. M. & Kohli, J., 3 Dec 2001, In: EMBO Journal. 20, 23, p. 6660-71 12 p.

    Research output: Contribution to journalArticlepeer-review

  13. Published

    Folic acid and rhodamine labelled pH responsive hyperbranched polymers: Synthesis, characterization and cell uptake studies

    Blackburn, C., Tai, H., Salerno, M., Wang, X., Hartsuiker, E. & Wang, W., Nov 2019, In: European Polymer Journal. 120, 109259.

    Research output: Contribution to journalArticlepeer-review

  14. Published

    Genetic Interaction Score (S-Score) Calculation, Clustering, and Visualization of Genetic Interaction Profiles for Yeast.

    Roguev, A., Ryan, C. J., Xu, J., Colson, I., Hartsuiker, E. & Krogan, N., Feb 2018, In: Cold Spring Harbor Protocols. 2018, 2

    Research output: Contribution to journalArticlepeer-review

  15. Published

    Genetic Interaction Screens in Schizosaccharomyces pombe Using the Pombe Epistasis Mapper (PEM) System and a Manual Colony Replicator.

    Colson, I. & Hartsuiker, E., Feb 2018, In: Cold Spring Harbor Protocols. 2018, 2

    Research output: Contribution to journalArticlepeer-review

  16. Published

    High-Throughput Quantitative Genetic Interaction Mapping in the Fission Yeast Schizosaccharomyces pombe.

    Roguev, A., Ryan, C. J., Hartsuiker, E. & Krogan, N. J., Feb 2018, In: Cold Spring Harbor Protocols. 2018, 2, p. 75-81 7 p.

    Research output: Contribution to journalArticlepeer-review

  17. Published

    Mre11 exonuclease activity removes the chain-terminating nucleoside analog gemcitabine from the nascent strand during DNA replication

    Böckemeier, L., Kraehenbuehl, R., Keszthelyi, A., Gasasira, M. U., Vernon, E., Beardmore, R., Broberg Vågbø, C., Chaplin, D., Collins, S., Krokan, H. E., Lambert, S. A. E., Paisz, B. & Hartsuiker, E., 29 May 2020, In: Science Advances. 6, 22, 9 p., eaaz4126.

    Research output: Contribution to journalArticlepeer-review

  18. Novel functional requirements for non-homologous DNA end joining in Schizosaccharomyces pombe

    Manolis, K. G., Nimmo, E. R., Hartsuiker, E., Carr, A. M., Jeggo, P. A. & Allshire, R. C., 15 Jan 2001, In: EMBO Journal. 20, 1-2, p. 210-21 12 p.

    Research output: Contribution to journalArticlepeer-review

  19. Published

    Roles of histone acetylation and chromatin remodeling factor in a meiotic recombination hotspot

    Yamada, T., Mizuno, K., Hirota, K., Kon, N., Wahls, W. P., Hartsuiker, E., Murofushi, H., Shibata, T. & Ohta, K., 21 Apr 2004, In: EMBO Journal. 23, 8, p. 1792-803 12 p.

    Research output: Contribution to journalArticlepeer-review

  20. Published

    Screening a genome-wide S.pombe deletion library identifies novel genes and pathways involved in genome stability maintenance.

    Deshpande, G. P., Hayles, J., Hoe, K. L., Kim, D. U., Park, H. O. & Hartsuiker, E., 1 May 2009, In: DNA Repair. 8, 5, p. 672-679

    Research output: Contribution to journalArticlepeer-review

  21. Published

    Selective Killing of BRCA2-Deficient Ovarian Cancer Cells via MRE11 Blockade

    Alblihy, A., Ali, R., Algethami, M., Ritchie, A. A., Shoqafi, A., Alqahtani, S., Mesquita, K. A., Toss, M. S., Ordóñez-Morán, P., Jeyapalan, J. N., Dekker, L., Salerno, M., Hartsuiker, E., Grabowska, A. M., Rakha, E. A., Mongan, N. P. & Madhusudan, S., 30 Jun 2023, In: International journal of molecular sciences. 24, 13

    Research output: Contribution to journalArticlepeer-review

  22. TDP1 facilitates repair of ionizing radiation-induced DNA single-strand breaks

    El-Khamisy, S. F., Hartsuiker, E. & Caldecott, K. W., 1 Oct 2007, In: DNA Repair. 6, 10, p. 1485-95 11 p.

    Research output: Contribution to journalArticlepeer-review

  23. Published

    The DNA-Binding Domain of S-pombe Mrc1 (Claspin) Acts to Enhance Stalling at Replication Barriers

    Zech, J., Godfrey, E. L., Masai, H., Hartsuiker, E. & Dalgaard, J. Z., 22 Jul 2015, In: PLoS ONE. 10, 7

    Research output: Contribution to journalArticlepeer-review

  24. Published

    The meiotic recombination hot spot ura4A in Schizosaccharomyces pombe

    Baur, M., Hartsuiker, E., Lehmann, E., Ludin, K., Munz, P. & Kohli, J., Feb 2005, In: Genetics. 169, 2, p. 551-61 11 p.

    Research output: Contribution to journalArticlepeer-review

  25. Published

    The msh2 gene of Schizosaccharomyces pombe is involved in mismatch repair, mating-type switching, and meiotic chromosome organization

    Rudolph, C., Kunz, C., Parisi, S., Lehmann, E., Hartsuiker, E., Fartmann, B., Kramer, W., Kohli, J. & Fleck, O., Jan 1999, In: Molecular and Cellular Biology. 19, 1, p. 241-50 10 p.

    Research output: Contribution to journalArticlepeer-review

  26. Published

    The role of topoisomerase II in meiotic chromosome condensation and segregation in Schizosaccharomyces pombe

    Hartsuiker, E., Bähler, J. & Kohli, J., Oct 1998, In: Molecular Biology of the Cell. 9, 10, p. 2739-50 12 p.

    Research output: Contribution to journalArticlepeer-review

  27. Published

    Topoisomerase I regulates open chromatin and controls gene expression in vivo

    Durand-Dubief, M., Persson, J., Norman, U., Hartsuiker, E. & Ekwall K., N. V., 7 Jul 2010, In: EMBO Journal. 29, 13, p. 2126 - 2134

    Research output: Contribution to journalArticlepeer-review

  28. Published

    UV induced ubiquitination of the yeast Rad4-Rad23 complex promotes survival by regulating cellular dNTP pools

    Zhou, Z., Humphryes, N., van Eijk, P., Waters, R., Yu, S. R., Kraehenbuehl, R., Hartsuiker, E. & Reed, S. H., 6 Jul 2015, In: Nucleic Acids Research. 43, 15, p. 7360-7370

    Research output: Contribution to journalArticlepeer-review

  29. Chapter › Research › Not peer-reviewed
  30. Published

    Detection of covalent DNA-bound Spo11 and topoisomerase complexes

    Hartsuiker, E. & Tsubouchi, H. (ed.), 28 Apr 2011, DNA recombination: Methods and Protocols. Springer Science and Business Media LLC, p. 65-77

    Research output: Chapter in Book/Report/Conference proceedingChapter

  31. Chapter › Research › Peer-reviewed
  32. Published

    Immunocytochemical techniques applied to meiotic chromosomes

    Heyting, C., Dietrich, A. J., de Jong, J. H. & Hartsuiker, E., 1994, Chromosome Analysis Protocols. Gosden, J. R. (ed.). Vol. 29. p. 287-302 (Methods in Molecular Biology).

    Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review