Dr Edgar Hartsuiker
Senior Lecturer in Biomedical Sciences (Cancer Biology)
- Article › Research › Peer-reviewed
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A 160-bp palindrome is a Rad50.Rad32-dependent mitotic recombination hotspot in Schizosaccharomyces pombe
Farah, J. A., Hartsuiker, E., Mizuno, K.-I., Ohta, K. & Smith, G. R., May 2002, In: Genetics. 161, 1, p. 461-8 8 p.Research output: Contribution to journal › Article › peer-review
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A simple Cre-loxP method for chromosomal N-terminal tagging of essential and non-essential Schizosaccharomyces pombe genes
Werler, P. J. H., Hartsuiker, E. & Carr, A. M., 30 Jan 2003, In: Gene. 304, p. 133-41 9 p.Research output: Contribution to journal › Article › peer-review
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A single unbranched S-phase DNA damage and replication fork blockage checkpoint pathway
Marchetti, M. A., Kumar, S., Hartsuiker, E., Maftahi, M., Carr, A. M., Freyer, G. A., Burhans, W. C. & Huberman, J. A., 28 May 2002, In: Proceedings of the National Academy of Sciences of the United States of America. 99, 11, p. 7472-7 6 p.Research output: Contribution to journal › Article › peer-review
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A supramodular FHA/BRCT-Repeat architecture mediates Nbs1 adaptor function in response to DNA damage.
Lloyd, J., Chapman, J. R., Clapperton, J. A., Haire, L. F., Hartsuiker, E., Li, J., Carr, A. M., Jackson, S. P. & Smerdon, S. J., 2 Oct 2009, In: Cell. 139, 1, p. 100-111Research output: Contribution to journal › Article › peer-review
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Collaborative Action of Brca1 and CtIP in Elimination of Covalent Modifications from Double-Strand Breaks to Facilitate Subsequent Break Repair
Nakamura, K., Kogame, T., Oshiumi, H., Shinohara, A., Sumitomo, Y., Agama, K., Pommier, Y., Tsutsui, K. M., Tsutsui, K., Hartsuiker, E., Ogi, T., Takeda, S. & Taniguchi, Y., 22 Jan 2010, In: PLOS Genetics. 6, 1Research output: Contribution to journal › Article › peer-review
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Ctp1CtIP and Rad32Mre11 nuclease activity are required for Rec12Spo11 removal, but Rec12Spo11 removal is dispensable for other MRN-dependent meiotic functions
Hartsuiker, E., Mizuno, K., Molnar, M., Kohli, J., Ohta, K. & Carr, A. M., Apr 2009, In: Molecular and Cellular Biology. 29, 7, p. 1671-1681 11 p.Research output: Contribution to journal › Article › peer-review
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Data presenting the synthesis of three novel stimuli responsive hyperbranched polymers synthesised via RAFT polymerisation and the bio conjugation of folic acid
Blackburn, C., Tai, H., Salerno, M., Wang, X., Senan, C., Ratcliffe, I., Hartsuiker, E. & Wang, W., Feb 2020, In: Data in Brief. 28, 104861.Research output: Contribution to journal › Article › peer-review
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Deoxynucleoside Salvage in Fission Yeast Allows Rescue of Ribonucleotide Reductase Deficiency but Not Spd1-Mediated Inhibition of Replication
Fleck, O., Fahnøe, U., Løvschal, K. V., Gasasira Uwamahoro, M.-F., Marinova, I. N., Kragelund, B. B., Carr, A. M., Hartsuiker, E., Holmberg, C. & Nielsen, O., 25 Apr 2017, In: Genes. 8, 5, 14 p., 128.Research output: Contribution to journal › Article › peer-review
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Distinct Requirements for the Rad32Mre11 Nuclease and Ctp1CtIP in the Removal of Covalently Bound Topoisomerase I and II from DNA
Hartsuiker, E., Neale, M. J. & Carr, A. M., 16 Jan 2009, In: Molecular Cell. 33, 1, p. 117-123Research output: Contribution to journal › Article › peer-review
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Double-strand break repair and homologous recombination in Schizosaccharomyces pombe
Raji, H. & Hartsuiker, E., 15 Oct 2006, In: Yeast. 23, 13, p. 963-76 14 p.Research output: Contribution to journal › Article › peer-review
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Fission yeast Rad50 stimulates sister chromatid recombination and links cohesion with repair
Hartsuiker, E., Vaessen, E., Carr, A. M. & Kohli, J., 3 Dec 2001, In: EMBO Journal. 20, 23, p. 6660-71 12 p.Research output: Contribution to journal › Article › peer-review
- Published
Folic acid and rhodamine labelled pH responsive hyperbranched polymers: Synthesis, characterization and cell uptake studies
Blackburn, C., Tai, H., Salerno, M., Wang, X., Hartsuiker, E. & Wang, W., Nov 2019, In: European Polymer Journal. 120, 109259.Research output: Contribution to journal › Article › peer-review
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Genetic Interaction Score (S-Score) Calculation, Clustering, and Visualization of Genetic Interaction Profiles for Yeast.
Roguev, A., Ryan, C. J., Xu, J., Colson, I., Hartsuiker, E. & Krogan, N., Feb 2018, In: Cold Spring Harbor Protocols. 2018, 2Research output: Contribution to journal › Article › peer-review
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Genetic Interaction Screens in Schizosaccharomyces pombe Using the Pombe Epistasis Mapper (PEM) System and a Manual Colony Replicator.
Colson, I. & Hartsuiker, E., Feb 2018, In: Cold Spring Harbor Protocols. 2018, 2Research output: Contribution to journal › Article › peer-review
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High-Throughput Quantitative Genetic Interaction Mapping in the Fission Yeast Schizosaccharomyces pombe.
Roguev, A., Ryan, C. J., Hartsuiker, E. & Krogan, N. J., Feb 2018, In: Cold Spring Harbor Protocols. 2018, 2, p. 75-81 7 p.Research output: Contribution to journal › Article › peer-review
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Mre11 exonuclease activity removes the chain-terminating nucleoside analog gemcitabine from the nascent strand during DNA replication
Böckemeier, L., Kraehenbuehl, R., Keszthelyi, A., Gasasira, M. U., Vernon, E., Beardmore, R., Broberg Vågbø, C., Chaplin, D., Collins, S., Krokan, H. E., Lambert, S. A. E., Paisz, B. & Hartsuiker, E., 29 May 2020, In: Science Advances. 6, 22, 9 p., eaaz4126.Research output: Contribution to journal › Article › peer-review
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Novel functional requirements for non-homologous DNA end joining in Schizosaccharomyces pombe
Manolis, K. G., Nimmo, E. R., Hartsuiker, E., Carr, A. M., Jeggo, P. A. & Allshire, R. C., 15 Jan 2001, In: EMBO Journal. 20, 1-2, p. 210-21 12 p.Research output: Contribution to journal › Article › peer-review
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Roles of histone acetylation and chromatin remodeling factor in a meiotic recombination hotspot
Yamada, T., Mizuno, K.-I., Hirota, K., Kon, N., Wahls, W. P., Hartsuiker, E., Murofushi, H., Shibata, T. & Ohta, K., 21 Apr 2004, In: EMBO Journal. 23, 8, p. 1792-803 12 p.Research output: Contribution to journal › Article › peer-review
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Screening a genome-wide S.pombe deletion library identifies novel genes and pathways involved in genome stability maintenance.
Deshpande, G. P., Hayles, J., Hoe, K. L., Kim, D. U., Park, H. O. & Hartsuiker, E., 1 May 2009, In: DNA Repair. 8, 5, p. 672-679Research output: Contribution to journal › Article › peer-review
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Selective Killing of BRCA2-Deficient Ovarian Cancer Cells via MRE11 Blockade
Alblihy , A., Ali , R., Algethami, M., Ritchie, A. A., Shoqafi, A., Alqahtani, S., Mesquita, K. A., Toss, M. S., Ordóñez-Morán , P., Jeyapalan, J. N., Dekker , L., Salerno, M., Hartsuiker, E., Grabowska , A. M., Rakha, E. A., Mongan, N. P. & Madhusudan, S., 30 Jun 2023, In: International journal of molecular sciences. 24, 13Research output: Contribution to journal › Article › peer-review
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TDP1 facilitates repair of ionizing radiation-induced DNA single-strand breaks
El-Khamisy, S. F., Hartsuiker, E. & Caldecott, K. W., 1 Oct 2007, In: DNA Repair. 6, 10, p. 1485-95 11 p.Research output: Contribution to journal › Article › peer-review
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The DNA-Binding Domain of S-pombe Mrc1 (Claspin) Acts to Enhance Stalling at Replication Barriers
Zech, J., Godfrey, E. L., Masai, H., Hartsuiker, E. & Dalgaard, J. Z., 22 Jul 2015, In: PLoS ONE. 10, 7Research output: Contribution to journal › Article › peer-review
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The meiotic recombination hot spot ura4A in Schizosaccharomyces pombe
Baur, M., Hartsuiker, E., Lehmann, E., Ludin, K., Munz, P. & Kohli, J., Feb 2005, In: Genetics. 169, 2, p. 551-61 11 p.Research output: Contribution to journal › Article › peer-review
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The msh2 gene of Schizosaccharomyces pombe is involved in mismatch repair, mating-type switching, and meiotic chromosome organization
Rudolph, C., Kunz, C., Parisi, S., Lehmann, E., Hartsuiker, E., Fartmann, B., Kramer, W., Kohli, J. & Fleck, O., Jan 1999, In: Molecular and Cellular Biology. 19, 1, p. 241-50 10 p.Research output: Contribution to journal › Article › peer-review
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The role of topoisomerase II in meiotic chromosome condensation and segregation in Schizosaccharomyces pombe
Hartsuiker, E., Bähler, J. & Kohli, J., Oct 1998, In: Molecular Biology of the Cell. 9, 10, p. 2739-50 12 p.Research output: Contribution to journal › Article › peer-review
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Topoisomerase I regulates open chromatin and controls gene expression in vivo
Durand-Dubief, M., Persson, J., Norman, U., Hartsuiker, E. & Ekwall K., [. V., 7 Jul 2010, In: EMBO Journal. 29, 13, p. 2126 - 2134Research output: Contribution to journal › Article › peer-review
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UV induced ubiquitination of the yeast Rad4-Rad23 complex promotes survival by regulating cellular dNTP pools
Zhou, Z., Humphryes, N., van Eijk, P., Waters, R., Yu, S. R., Kraehenbuehl, R., Hartsuiker, E. & Reed, S. H., 6 Jul 2015, In: Nucleic Acids Research. 43, 15, p. 7360-7370Research output: Contribution to journal › Article › peer-review
- Chapter › Research › Not peer-reviewed
- Published
Detection of covalent DNA-bound Spo11 and topoisomerase complexes
Hartsuiker, E. & Tsubouchi, H. (Editor), 28 Apr 2011, DNA recombination: Methods and Protocols. Springer Science and Business Media LLC, p. 65-77Research output: Chapter in Book/Report/Conference proceeding › Chapter
- Chapter › Research › Peer-reviewed
- Published
Immunocytochemical techniques applied to meiotic chromosomes
Heyting, C., Dietrich, A. J., de Jong, J. H. & Hartsuiker, E., 1994, Chromosome Analysis Protocols. Gosden, J. R. (ed.). Vol. 29. p. 287-302 (Methods in Molecular Biology).Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review