A neuroanatomical and cognitive model of impaired social behaviour in frontotemporal dementia
Research output: Contribution to journal › Review article › peer-review
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DOI
Impaired social cognition is a core deficit in frontotemporal dementia (FTD). It is most commonly associated with the behavioural-variant of FTD, with atrophy of the orbitofrontal and ventromedial prefrontal cortex. Social cognitive changes are also common in semantic dementia, with atrophy centred on the anterior temporal lobes. The impairment of social behaviour in FTD has typically been attributed to damage to the orbitofrontal cortex and/or temporal poles and/or the uncinate fasciculus that connects them. However, the relative contributions of each region are unresolved. In this Review, we present a unified neurocognitive model of controlled social behaviour that not only explains the observed impairment of social behaviours in FTD, but also assimilates both consistent and potentially contradictory findings from other patient groups, comparative neurology and normative cognitive neuroscience. We propose that impaired social behaviour results from damage to two cognitively- and anatomically-distinct components. The first component is social-semantic knowledge, a part of the general semantic-conceptual system supported by the anterior temporal lobes bilaterally. The second component is social control, supported by the orbitofrontal cortex, medial frontal cortex and ventrolateral frontal cortex, which interacts with social-semantic knowledge to guide and shape social behaviour.
Keywords
- frontotemporal dementia, semantic dementia, social-semantic knowledge, social control, anterior temporal lobe, orbitofrontal cortex
Original language | English |
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Journal | Brain |
Early online date | 9 Feb 2024 |
DOIs | |
Publication status | E-pub ahead of print - 9 Feb 2024 |
Research outputs (3)
- Published
Social Semantics: The Organisation and Grounding of Abstract Concepts
Research output: Contribution to journal › Review article › peer-review
- Published
The Role of the Ventrolateral Anterior Temporal Lobes in Social Cognition
Research output: Contribution to journal › Article › peer-review
- Published
Social Semantics: The role of conceptual knowledge and cognitive control in a neurobiological model of the social brain
Research output: Contribution to journal › Review article › peer-review