Biocatalyst mediated regio- and stereo-selective hydroxylation and epoxidation of (Z)-α-santalol
Research output: Contribution to journal › Article › peer-review
Electronic versions
DOI
Biocatalyst mediated regio- and stereo-selective hydroxylation and epoxidation on (Z)-α-santalol were achieved for the first time, using a fungal strain Mucor piriformis. Four novel metabolites were characterized as 10,11-cis-β-epoxy-α-santalol, 5α-hydroxy-(Z)-α-santalol, 10,11-dihydroxy-α-santalol and 5α-hydroxy-10,11-cis-β-epoxy-α-santalol. Using Amano PS lipase from Burkholderia cepacia, α- and β-isomers of 10,11-cis-epoxy-α-santalol were resolved efficiently.
Keywords
- Biocatalysis, Burkholderia cepacia/enzymology, Hydroxylation, Lipase/metabolism, Molecular Conformation, Mucor/metabolism, Polycyclic Sesquiterpenes, Sesquiterpenes/metabolism, Stereoisomerism
Original language | English |
---|---|
Pages (from-to) | 1048-51 |
Number of pages | 4 |
Journal | Organic and Biomolecular Chemistry |
Volume | 12 |
Issue number | 7 |
DOIs | |
Publication status | Published - 21 Feb 2014 |
Externally published | Yes |