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Biocatalyst mediated regio- and stereo-selective hydroxylation and epoxidation of (Z)-α-santalol

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Biocatalyst mediated regio- and stereo-selective hydroxylation and epoxidation of (Z)-α-santalol. / Daramwar, Pankaj P; Srivastava, Prabhakar Lal; Kolet, Swati P et al.
In: Organic and Biomolecular Chemistry, Vol. 12, No. 7, 21.02.2014, p. 1048-51.

Research output: Contribution to journal › Article › peer-review

HarvardHarvard

Daramwar, PP, Srivastava, PL, Kolet, SP & Thulasiram, HV 2014, 'Biocatalyst mediated regio- and stereo-selective hydroxylation and epoxidation of (Z)-α-santalol', Organic and Biomolecular Chemistry, vol. 12, no. 7, pp. 1048-51. https://doi.org/10.1039/c3ob42174k

APA

Daramwar, P. P., Srivastava, P. L., Kolet, S. P., & Thulasiram, H. V. (2014). Biocatalyst mediated regio- and stereo-selective hydroxylation and epoxidation of (Z)-α-santalol. Organic and Biomolecular Chemistry, 12(7), 1048-51. https://doi.org/10.1039/c3ob42174k

CBE

Daramwar PP, Srivastava PL, Kolet SP, Thulasiram HV. 2014. Biocatalyst mediated regio- and stereo-selective hydroxylation and epoxidation of (Z)-α-santalol. Organic and Biomolecular Chemistry. 12(7):1048-51. https://doi.org/10.1039/c3ob42174k

MLA

Daramwar, Pankaj P et al. "Biocatalyst mediated regio- and stereo-selective hydroxylation and epoxidation of (Z)-α-santalol". Organic and Biomolecular Chemistry. 2014, 12(7). 1048-51. https://doi.org/10.1039/c3ob42174k

VancouverVancouver

Daramwar PP, Srivastava PL, Kolet SP, Thulasiram HV. Biocatalyst mediated regio- and stereo-selective hydroxylation and epoxidation of (Z)-α-santalol. Organic and Biomolecular Chemistry. 2014 Feb 21;12(7):1048-51. doi: 10.1039/c3ob42174k

Author

Daramwar, Pankaj P ; Srivastava, Prabhakar Lal ; Kolet, Swati P et al. / Biocatalyst mediated regio- and stereo-selective hydroxylation and epoxidation of (Z)-α-santalol. In: Organic and Biomolecular Chemistry. 2014 ; Vol. 12, No. 7. pp. 1048-51.

RIS

TY - JOUR

T1 - Biocatalyst mediated regio- and stereo-selective hydroxylation and epoxidation of (Z)-α-santalol

AU - Daramwar, Pankaj P

AU - Srivastava, Prabhakar Lal

AU - Kolet, Swati P

AU - Thulasiram, Hirekodathakallu V

PY - 2014/2/21

Y1 - 2014/2/21

N2 - Biocatalyst mediated regio- and stereo-selective hydroxylation and epoxidation on (Z)-α-santalol were achieved for the first time, using a fungal strain Mucor piriformis. Four novel metabolites were characterized as 10,11-cis-β-epoxy-α-santalol, 5α-hydroxy-(Z)-α-santalol, 10,11-dihydroxy-α-santalol and 5α-hydroxy-10,11-cis-β-epoxy-α-santalol. Using Amano PS lipase from Burkholderia cepacia, α- and β-isomers of 10,11-cis-epoxy-α-santalol were resolved efficiently.

AB - Biocatalyst mediated regio- and stereo-selective hydroxylation and epoxidation on (Z)-α-santalol were achieved for the first time, using a fungal strain Mucor piriformis. Four novel metabolites were characterized as 10,11-cis-β-epoxy-α-santalol, 5α-hydroxy-(Z)-α-santalol, 10,11-dihydroxy-α-santalol and 5α-hydroxy-10,11-cis-β-epoxy-α-santalol. Using Amano PS lipase from Burkholderia cepacia, α- and β-isomers of 10,11-cis-epoxy-α-santalol were resolved efficiently.

KW - Biocatalysis

KW - Burkholderia cepacia/enzymology

KW - Hydroxylation

KW - Lipase/metabolism

KW - Molecular Conformation

KW - Mucor/metabolism

KW - Polycyclic Sesquiterpenes

KW - Sesquiterpenes/metabolism

KW - Stereoisomerism

U2 - 10.1039/c3ob42174k

DO - 10.1039/c3ob42174k

M3 - Article

C2 - 24407157

VL - 12

SP - 1048

EP - 1051

JO - Organic and Biomolecular Chemistry

JF - Organic and Biomolecular Chemistry

SN - 1477-0520

IS - 7

ER -