Brachyury: Strategies for Drugging an Intractable Cancer Therapeutic Target
Research output: Contribution to journal › Article › peer-review
Electronic versions
DOI
New approaches to drug discovery are unlocking enormous therapeutic potential residing in cancer-specific molecules. Brachyury is emerging as an exciting new drug target for the rare bone cancer chordoma. Here, recent advances targeting Brachyury in chordoma are discussed and how these might open doors to the targeting of other, more common cancer types.
Keywords
- Antineoplastic Agents/pharmacology, Biomarkers, Tumor/analysis, Bone Neoplasms/diagnosis, Chordoma/diagnosis, Computer Simulation, Crystallography, X-Ray, Drug Discovery, Fetal Proteins/analysis, Humans, Models, Molecular, Protein Domains, T-Box Domain Proteins/analysis
| Original language | English |
|---|---|
| Pages (from-to) | 271-273 |
| Number of pages | 3 |
| Journal | Trends in cancer |
| Volume | 6 |
| Issue number | 4 |
| DOIs | |
| Publication status | Published - Apr 2020 |