Research Portal

Brachyury: Strategies for Drugging an Intractable Cancer Therapeutic Target

Research output: Contribution to journal › Article › peer-review

Standard Standard

Brachyury: Strategies for Drugging an Intractable Cancer Therapeutic Target. / Robinson, Helena; McFarlane, Ramsay J; Wakeman, Jane A.
In: Trends in cancer, Vol. 6, No. 4, 04.2020, p. 271-273.

Research output: Contribution to journal › Article › peer-review

HarvardHarvard

Robinson, H, McFarlane, RJ & Wakeman, JA 2020, 'Brachyury: Strategies for Drugging an Intractable Cancer Therapeutic Target', Trends in cancer, vol. 6, no. 4, pp. 271-273. https://doi.org/10.1016/j.trecan.2020.01.014

APA

Robinson, H., McFarlane, R. J., & Wakeman, J. A. (2020). Brachyury: Strategies for Drugging an Intractable Cancer Therapeutic Target. Trends in cancer, 6(4), 271-273. https://doi.org/10.1016/j.trecan.2020.01.014

CBE

Robinson H, McFarlane RJ, Wakeman JA. 2020. Brachyury: Strategies for Drugging an Intractable Cancer Therapeutic Target. Trends in cancer. 6(4):271-273. https://doi.org/10.1016/j.trecan.2020.01.014

MLA

Robinson, Helena, Ramsay J McFarlane and Jane A Wakeman. "Brachyury: Strategies for Drugging an Intractable Cancer Therapeutic Target". Trends in cancer. 2020, 6(4). 271-273. https://doi.org/10.1016/j.trecan.2020.01.014

VancouverVancouver

Robinson H, McFarlane RJ, Wakeman JA. Brachyury: Strategies for Drugging an Intractable Cancer Therapeutic Target. Trends in cancer. 2020 Apr;6(4):271-273. doi: 10.1016/j.trecan.2020.01.014

Author

Robinson, Helena ; McFarlane, Ramsay J ; Wakeman, Jane A. / Brachyury: Strategies for Drugging an Intractable Cancer Therapeutic Target. In: Trends in cancer. 2020 ; Vol. 6, No. 4. pp. 271-273.

RIS

TY - JOUR

T1 - Brachyury: Strategies for Drugging an Intractable Cancer Therapeutic Target

AU - Robinson, Helena

AU - McFarlane, Ramsay J

AU - Wakeman, Jane A

N1 - Copyright © 2020 Elsevier Inc. All rights reserved.

PY - 2020/4

Y1 - 2020/4

N2 - New approaches to drug discovery are unlocking enormous therapeutic potential residing in cancer-specific molecules. Brachyury is emerging as an exciting new drug target for the rare bone cancer chordoma. Here, recent advances targeting Brachyury in chordoma are discussed and how these might open doors to the targeting of other, more common cancer types.

AB - New approaches to drug discovery are unlocking enormous therapeutic potential residing in cancer-specific molecules. Brachyury is emerging as an exciting new drug target for the rare bone cancer chordoma. Here, recent advances targeting Brachyury in chordoma are discussed and how these might open doors to the targeting of other, more common cancer types.

KW - Antineoplastic Agents/pharmacology

KW - Biomarkers, Tumor/analysis

KW - Bone Neoplasms/diagnosis

KW - Chordoma/diagnosis

KW - Computer Simulation

KW - Crystallography, X-Ray

KW - Drug Discovery

KW - Fetal Proteins/analysis

KW - Humans

KW - Models, Molecular

KW - Protein Domains

KW - T-Box Domain Proteins/analysis

U2 - 10.1016/j.trecan.2020.01.014

DO - 10.1016/j.trecan.2020.01.014

M3 - Article

C2 - 32209441

VL - 6

SP - 271

EP - 273

JO - Trends in cancer

JF - Trends in cancer

SN - 2405-8033

IS - 4

ER -