Real-time detection of DNA interactions with long-period fiber-grating-based biosensor

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DOI

  • Xianfeng Chen
  • L. Zhang
  • K. Zhou
  • E. Davies
  • K. Sugden
  • I. Bennion
  • M. Hughes
  • A.V. Hine
Using an optical biosensor based on a dual-peak long-period fiber grating, we have demonstrated the detection of interactions between biomolecules in real time. Silanization of the grating surface was successfully realized for the covalent immobilization of probe DNA, which was subsequently hybridized with the complementary target DNA sequence. It is interesting to note that the DNA biosensor was reusable after being stripped off the hybridized target DNA from the grating surface, demonstrating a function of multiple usability.
Original languageEnglish
Pages (from-to)2541-2543
JournalOptics Letters
Volume32
Issue number17
DOIs
Publication statusPublished - Sept 2007
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