Electronic versions

  • Joanna Moss
    University of Birmingham
  • Patricia Howlin
    King's College London
  • Richard Patrick Hastings
  • Sarah Beaumont
    University of Birmingham
  • Gemma M Griffith
  • Jane Petty
    University of Birmingham
  • Penny Tunnicliffe
    University of Birmingham
  • Rachel Yates
    King's College London
  • Darrelle Villa
    University of Birmingham
  • Chris Oliver
    University of Birmingham

We evaluated autism spectrum disorder (ASD) characteristics and social behavior in Angelman (AS; n  =  19; mean age  = 10.35 years), Cornelia de Lange (CdLS; n  =  15; mean age  = 12.40 years), and Cri du Chat (CdCS, also known as 5 p-syndrome; n  =  19; mean age  =  8.80 years) syndromes. The proportion of individuals meeting the ASD cutoff on the Social Communication Questionnaire was significantly higher in the AS and CdLS groups than in the CdCS group (p < .01). The groups demonstrated divergent social behavior profiles during social conditions in which adult availability, adult familiarity, and social demand were manipulated. Social enjoyment was significantly heightened in AS, whereas social approaches were heightened in individuals with CdCS. Social motivation, social communication, and enjoyment were significantly lower in CdLS. The findings highlight the importance of detailed observation when evaluating ASD and social behavior in genetic syndromes.

Keywords

  • Adolescent, Adult, Angelman Syndrome, Child, Child Development Disorders, Pervasive, Child, Preschool, Comorbidity, Cri-du-Chat Syndrome, De Lange Syndrome, Female, Humans, Interpersonal Relations, Male, Phenotype, Psychiatric Status Rating Scales, Psychological Tests, Qualitative Research, Social Behavior, Surveys and Questionnaires, Young Adult, Comparative Study, Journal Article
Original languageEnglish
Pages (from-to)262-83
Number of pages22
JournalAmerican Journal on Intellectual and Developmental Disabilities
Volume118
Issue number4
DOIs
Publication statusPublished - Jul 2013
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