TY - JOUR

T1 - Social behavior and characteristics of autism spectrum disorder in Angelman, Cornelia de Lange, and Cri du Chat syndromes

AU - Moss, Joanna

AU - Howlin, Patricia

AU - Hastings, Richard Patrick

AU - Beaumont, Sarah

AU - Griffith, Gemma M

AU - Petty, Jane

AU - Tunnicliffe, Penny

AU - Yates, Rachel

AU - Villa, Darrelle

AU - Oliver, Chris

PY - 2013/7

Y1 - 2013/7

N2 - We evaluated autism spectrum disorder (ASD) characteristics and social behavior in Angelman (AS; n  =  19; mean age  = 10.35 years), Cornelia de Lange (CdLS; n  =  15; mean age  = 12.40 years), and Cri du Chat (CdCS, also known as 5 p-syndrome; n  =  19; mean age  =  8.80 years) syndromes. The proportion of individuals meeting the ASD cutoff on the Social Communication Questionnaire was significantly higher in the AS and CdLS groups than in the CdCS group (p < .01). The groups demonstrated divergent social behavior profiles during social conditions in which adult availability, adult familiarity, and social demand were manipulated. Social enjoyment was significantly heightened in AS, whereas social approaches were heightened in individuals with CdCS. Social motivation, social communication, and enjoyment were significantly lower in CdLS. The findings highlight the importance of detailed observation when evaluating ASD and social behavior in genetic syndromes.

AB - We evaluated autism spectrum disorder (ASD) characteristics and social behavior in Angelman (AS; n  =  19; mean age  = 10.35 years), Cornelia de Lange (CdLS; n  =  15; mean age  = 12.40 years), and Cri du Chat (CdCS, also known as 5 p-syndrome; n  =  19; mean age  =  8.80 years) syndromes. The proportion of individuals meeting the ASD cutoff on the Social Communication Questionnaire was significantly higher in the AS and CdLS groups than in the CdCS group (p < .01). The groups demonstrated divergent social behavior profiles during social conditions in which adult availability, adult familiarity, and social demand were manipulated. Social enjoyment was significantly heightened in AS, whereas social approaches were heightened in individuals with CdCS. Social motivation, social communication, and enjoyment were significantly lower in CdLS. The findings highlight the importance of detailed observation when evaluating ASD and social behavior in genetic syndromes.

KW - Adolescent

KW - Adult

KW - Angelman Syndrome

KW - Child

KW - Child Development Disorders, Pervasive

KW - Child, Preschool

KW - Comorbidity

KW - Cri-du-Chat Syndrome

KW - De Lange Syndrome

KW - Female

KW - Humans

KW - Interpersonal Relations

KW - Male

KW - Phenotype

KW - Psychiatric Status Rating Scales

KW - Psychological Tests

KW - Qualitative Research

KW - Social Behavior

KW - Surveys and Questionnaires

KW - Young Adult

KW - Comparative Study

KW - Journal Article

U2 - 10.1352/1944-7558-118.4.262

DO - 10.1352/1944-7558-118.4.262

M3 - Article

C2 - 23937369

VL - 118

SP - 262

EP - 283

JO - American Journal on Intellectual and Developmental Disabilities

JF - American Journal on Intellectual and Developmental Disabilities

SN - 1944-7515

IS - 4

ER -