The genetics of the repaor of 5-azacytidine-mediated DNA damage in the fission yeast Schizosaccharomyces pombe.
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We have recently demonstrated that Schizosaccharomyces pombe cells treated with the nucleoside analogue 5-azacytidine (5-azaC) require previously characterised G2 checkpoint mechanisms for survival. Here we present a survey of known DNA repair mutations which defines those genes required for survival in the presence of 5-azaC. Using a combination of single-mutant and epistasis analyses we find that the excision, mismatch and recombinational repair pathways are all required in some degree for the repair of 5-azaC-mediated DNA damage. There are distinct differences in the epistatic interactions of several of the repair mutations with respect to 5-azaC-mediated DNA damage relative to UV-mediated DNA damage.
| Original language | English |
|---|---|
| Pages (from-to) | 483-492 |
| Journal | Molecular Genetics and Genomics |
| Volume | 251 |
| Issue number | 4 |
| DOIs | |
| Publication status | Published - 1 Jun 1996 |