Translin-Trax: Considerations for Oncological Therapeutic Targeting
Research output: Contribution to journal › Article › peer-review
Electronic versions
Dicer-deficient cancers have poor prognoses, which is linked to the degradation of tumour-suppressing miRNA precursors by the Translin-Trax (Tn-Tx) ribonuclease. Inhibition of Tn-Tx potentially offers a new therapeutic intervention point. However, Tn-Tx functions in an array of biological processes, and here we consider how this complexity could influence therapeutic design strategies.
Keywords
- Translin-Trax, Dicer, drug development, miRNA, DNA repair
| Original language | English |
|---|---|
| Pages (from-to) | 450-453 |
| Number of pages | 4 |
| Journal | Trends in Cancer |
| Volume | 6 |
| Issue number | 6 |
| Early online date | 16 Mar 2020 |
| DOIs | |
| Publication status | Published - Jun 2020 |