Professor Alexander Yakunin

Professor In Enzyme Discovery and Application

Contact info

 

Professor Alexander Yakunin (Iakounine)

 

Office: Thoday Building, room S25

Email: a.iakounine@bangor.ac.uk

Tel: 01248 388399

 

Research focus: enzyme discovery, enzymology, enzyme applications

  1. Article › Research › Peer-reviewed
  2. Structural Insights into Substrate Selectivity and Activity of Bacterial Polyphosphate Kinases

    Nocek, B. P., Khusnutdinova, A. N., Ruszkowski, M., Flick, R., Burda, M., Batyrova, K., Brown, G., Mucha, A., Joachimiak, A., Berlicki, L. & Yakunin, A. F., 2 Nov 2018, In: ACS Catalysis. 8, 11, p. 10746-10760

    Research output: Contribution to journalArticlepeer-review

  3. Published

    Structural and biochemical insights into CRISPR RNA processing by the Cas5c ribonuclease SMU1763 from Streptococcus mutans

    Lemak, S., Serbanescu, M. A., Khusnutdinova, A. N., Ruszkowski, M., Beloglazova, N., Xu, X., Brown, G., Cui, H., Tan, K., Joachimiak, A., Cvitkovitch, D. G., Savchenko, A. & Yakunin, A., Nov 2021, In: Journal of Biological Chemistry. 297, 5, 101251.

    Research output: Contribution to journalArticlepeer-review

  4. Published

    Structural insights into hydrolytic defluorination of difluoroacetate by microbial fluoroacetate dehalogenases

    Khusnutdinova, A. N., Batyrova, K., Brown, G., Fedorchuck, T., Chai, Y. S., Skarina, T., Flick, R., Petit, A-P., Savchenko, A., Stogios, P. & Yakunin, A., Oct 2023, In: Febs Journal. 290, 20, p. 4966-4983 18 p.

    Research output: Contribution to journalArticlepeer-review

  5. Published

    Structure and activity of the cold-active and anion-activated carboxyl esterase OLEI01171 from the oil-degrading marine bacterium Oleispira antarctica

    Lemak, S., Tchigvintsev, A., Petit, P., Flick, R., Singer, A. U., Brown, G., Evdokimova, E., Egorova, O., Gonzalez, C. F., Chernikova, T. N., Yakimov, M. M., Kube, M., Reinhardt, R., Golyshin, P. N., Savchenko, A. & Yakunin, A. F., 15 Jul 2012, In: Biochemical Journal. 445, 2, p. 193-203

    Research output: Contribution to journalArticlepeer-review

  6. The CRISPR-associated Cas4 protein Pcal_0546 from Pyrobaculum calidifontis contains a [2Fe-2S] cluster: crystal structure and nuclease activity

    Lemak, S., Nocek, B., Beloglazova, N., Skarina, T., Flick, R., Brown, G., Joachimiak, A., Savchenko, A. & Yakunin, A. F., 29 Sept 2014, In: Nucleic Acids Research. 42, 17, p. 11144-11155

    Research output: Contribution to journalArticlepeer-review

  7. Published

    The environment shapes microbial enzymes: five cold-active and salt-resistant carboxylesterases from marine metagenomes

    Tchigvintsev, A., Tran, H., Popvic, A., Kovacic, F., Brown, G., Flick, R., Hajighasemi, M., Egorova, O., Somody, J. C., Tchigvintsev, D., Khusnutdinova, A., Chernikova, T. N., Golyshina, O., Yakimov, M. M., Savchenko, A., Golyshin, P., Jaeger, K. E. & Yakunin, A. F., 1 Mar 2015, In: Applied Microbiology and Biotechnology. 99, 5, p. 2165-2178

    Research output: Contribution to journalArticlepeer-review

  8. Published

    Thermophilic Carboxylesterases from Hydrothermal Vents of the Volcanic Island of Ischia Active on Synthetic and Biobased Polymers and Mycotoxins

    Distaso, M., Chernikova, T., Bargiela, R., Coscolín, C., Stogios, P. J., Gonzalez-Alfonso, J. L., Lemak, S., Khusnutdinova, A., Plou, F. J., Evdokimova, E., Savchenko, A., Lunev, E., Yakimov, M. M., Golyshina, O., Ferrer, M., Yakunin, A. & Golyshin, P., 28 Feb 2023, In: Applied and Environmental Microbiology. 89, 2, p. e0170422 20 p.

    Research output: Contribution to journalArticlepeer-review

  9. Chapter › Research › Peer-reviewed
  10. Published

    Metagenomics as a tool for enzyme discovery: hydrolytic enzymes from marine-related metagenomes

    Popovic, A., Tchigvintsev, A., Tran, H., Chernikova, T. N., Golyshina, O. V., Yakimov, M. M., Golyshin, P. N. & Yakunin, A. F., 2015, Prokaryotic Systems Biology. Springer, p. 1-20 20 p.

    Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

  11. Published

    Prenylated FMN: biosynthesis, purification, and Fdc1 activation

    Khusnutdinova, A. N., Xiao, J., Wang, P-H., Batyrova, K., Flick, R., Edwards, E. & Yakunin, A., 2019, New Approaches for Flavin Catalysis. Palfey, B. A. (ed.). Elsevier, Vol. 620. p. 469-488 (Methods in Enzymology).

    Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

  12. Review article › Research › Peer-reviewed
  13. Published

    Harnessing extremophilic carboxylesterases for applications in polyester depolymerisation and plastic waste recycling

    Williams, G., Ma, H., Khusnutdinova, A., Yakunin, A. & Golyshin, P., Aug 2023, In: Essays in Biochemistry. 67, 4, p. 715-729 15 p., EBC20220255.

    Research output: Contribution to journalReview articlepeer-review

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