1. Article › Research › Peer-reviewed
2. Published

   Economic evaluation of a behavior-modifying intervention to enhance antiepileptic drug adherence

   Hughes, D., Plumpton, C. O., Brown, I., Reuber, M., Marson, A. G. & Hughes, D. A., 26 Mar 2015, In: Epilepsy and Behavior. 45, p. 180-186

   Research output: Contribution to journal › Article › peer-review

3. Published

   Economic evaluations during early (Phase II) drug development: A role for clinical trial simulations.

   Hughes, D., Hughes, D. A. & Walley, T., 1 Jan 2001, In: Pharmacoeconomics. 19, 11, p. 1069-1077

   Research output: Contribution to journal › Article › peer-review

4. Published

   Economic impact of poor compliance with pharmaceuticals.

   Hughes, D. & Hughes, D. A., 1 Aug 2002, In: Expert Review of Pharmacoeconomics and Outcomes Research. 2, 4, p. 327-335

   Research output: Contribution to journal › Article › peer-review

5. Published

   Economics of pharmacogenetic guided treatments: Underwhelming or overstated?

   Hughes, D., May 2018, In: Clinical Pharmacology and Therapeutics. 103, 5, p. 749-751

   Research output: Contribution to journal › Article › peer-review

6. Published

   Effectiveness of out-patient based acute heart failure care: A pilot randomised controlled trial

   Wong, K. Y. K., Hughes, D., Debski, M., Latt, N., Assaf, O., Abdelrahman, A., Taylor, R., Allgar, V., McNeill, L., Howard, S., Wong, S. Y. S., Jones, R., Cassidy, C. J., Seed, A., Galasko, G., Clark, A., Davis, G. K., Montasem, A., Lang, C. C., Kalra, P. R., Campbell, R., Lip, G. Y. H. & Cleland, J. G. F., Oct 2023, In: Acta Cardiologica. 78, 7, p. 828-837 10 p.

   Research output: Contribution to journal › Article › peer-review

7. Published

   Effects of the abolition of prescription charges in Wales: a preliminary analysis.

   Hughes, D., Cohen, D., Alam, M. F., Hughes, D. A., Dunstan, F. & Routledge, P., 1 Jan 2008, In: International Journal of Pharmacy Practice. 16, Supplement 1, p. A39

   Research output: Contribution to journal › Article › peer-review

8. Published

   EstablishINg the best STEp-up treatments for children with uncontrolled asthma despite INhaled corticosteroids (EINSTEIN): Protocol for a systematic review, network meta-analysis and cost-effectiveness analysis using individual participant data (IPD)

   Cividini, S., Sinha, I., Donegan, S., Maden, M., Culeddu, G., Rose, K., Fulton, O., Hughes, D., Turner, S. & Smith, C. T., 5 Feb 2021, In: BMJ Open. 11, e040528.

   Research output: Contribution to journal › Article › peer-review

9. Published

   Estimating Drug Costs in Economic Evaluations in Ireland and the UK: An Analysis of Practice and Research Recommendations.

   Hughes, D., Hughes, D. A., Tilson, L. & Drummond, M. F., 1 May 2009, In: Pharmacoeconomics. 27, 8, p. 635-643

   Research output: Contribution to journal › Article › peer-review

10. Published

    Estimation of the impact of noncompliance on pharmacokinetics: an analysis of the influence of dosing regimens

    Hughes, D. & Hughes, D. A., 1 Dec 2008, In: British Journal of Clinical Pharmacology. 65, 6, p. 871-878

    Research output: Contribution to journal › Article › peer-review

11. Published

    Evaluation of a consultant audit and feedback programme to improve the quality of antimicrobial prescribing in acute medical admissions

    Hughes, D., Roberts, E., Dawoud, D. M., Hughes, D. A. & Cefai, C., 1 Oct 2015, In: International Journal of Pharmacy Practice. 23, 5, p. 333-339

    Research output: Contribution to journal › Article › peer-review

12. Published

    Experiences of men who have sex with men when initiating, implementing, and persisting with HIV pre-exposure prophylaxis

    Gillespie, D., Wood, F., Williams, A., Ma, R., de Bruin, M., Hughes, D., Jones, A. T., Couzens, Z. & Hood, K., Aug 2022, In: Health Expectations. 25, 4, p. 1332-1341 10 p.

    Research output: Contribution to journal › Article › peer-review

13. Published

    Extended-release pharmacotherapy for opioid use disorder (EXPO): protocol for an open-label randomised controlled trial of the effectiveness and cost-effectiveness of injectable buprenorphine versus sublingual tablet buprenorphine and oral liquid methadone

    Marsden, J., Kelleher, M., Hoare, Z., Hughes, D., Bisla, J., Cape, A., Cowden, F., Day, E., Dewhurst, J., Evans, R., Hearn, A., Kelly, J., Lowry, N., McCusker, M., Murphy, C., Murray, R., Myton, T., Quarshie, S., Scott, G., Turner, S., Vanderwaal, R., Wareham, A., Gilvarry, E. & Mitcheson, L., 19 Aug 2022, In: Trials. 23, 1, 697.

    Research output: Contribution to journal › Article › peer-review

14. Published

    Factors influencing user choices to visit either general practitioners or community pharmacists for minor ailments – a discrete choice experiment

    Hughes, D., Hughes, D. A., Myles, S., Longo, M., Lisles, C. & Hood, K., 1 Jan 2007, In: Value in Health. 10, 3, p. A23

    Research output: Contribution to journal › Article › peer-review

15. Published

    Feasibility, validity and reliability of the Welsh version of the EQ-5D health status questionnaire.

    Hughes, D. & Hughes, D. A., 1 Oct 2007, In: Quality of Life Research. 16, 8, p. 1419-1423

    Research output: Contribution to journal › Article › peer-review

16. Published

    Feasibility, validity, and reliability of the Welsh version of the EQ-5D health status questionnaire

    Hughes, D. & Hughes, D. A., 1 Jan 2007, In: Value in Health. 10, 3, p. A189

    Research output: Contribution to journal › Article › peer-review

17. Published

    Folate Augmentation of Treatment – Evaluation for Depression (FolATED): protocol of a randomised controlled trial.

    Russell, I. T., Slegg, G. P., Roberts, S. H., Bedson, E., Hughes, D., Lloyd, K., Moat, S., Pirmohamed, M., Slegg, G., Tranter, R., Whitaker, R., Wilkinson, C. & Russell, I., 15 Nov 2007, In: BMC Psychiatry. 7, 1, p. 65

    Research output: Contribution to journal › Article › peer-review

18. Published

    Folate Augmentation of Treatment-Evaluation for Depression (FolATED): randomised trial and economic evaluation

    Bedson, E., Bell, D., Carr, D., Carter, B., Hughes, D., Jorgensen, A., Lewis, H., Lloyd, K., McCaddon, A., Moat, S., Pink, J., Pirmohamed, M., Roberts, S., Russell, I., Sylvestre, Y., Tranter, R., Whitaker, R., Wilkinson, C. & Williams, N., Jul 2014, In: Health Technology Assessment. 18, 48, p. 1-159

    Research output: Contribution to journal › Article › peer-review

19. Published

    Follow-up of cancer in primary care versus secondary care: systematic review

    Lewis, R. A., Neal, R. D., Williams, N. H., France, B., Hendry, M., Russell, D., Hughes, D. A., Russell, I., Stuart, N. S. A., Weller, D. & Wilkinson, C., 1 Jul 2009, In: British Journal of General Practice. 59, 564, p. e234-e247

    Research output: Contribution to journal › Article › peer-review

20. Published

    From NCE to NICE: the role of pharmacoeconomics

    Hughes, D. & Hughes, D. A., 1 Sept 2010, In: British Journal of Clinical Pharmacology. 70, 3, p. 317-319

    Research output: Contribution to journal › Article › peer-review

21. Published

    Generalisability and Cost-Impact of Antibiotic-Impregnated Central Venous Catheters for Reducing Risk of Bloodstream Infection in Paediatric Intensive Care Units in England

    Harron, K., Mok, Q., Hughes, D., Muller-Pebody, B., Parslow, R., Ramnarayan, P. & Gilbert, R., 21 Mar 2016, In: PLoS ONE. 11, 3, p. e0151348

    Research output: Contribution to journal › Article › peer-review

22. Published

    Generic and therapeutic substitutions in the UK: are they a good thing?

    Hughes, D., Duerden, M. G. & Hughes, D. A., 1 Sept 2010, In: British Journal of Clinical Pharmacology. 70, 3, p. 335-341

    Research output: Contribution to journal › Article › peer-review

23. Published

    Genetic and environmental factors determining clinical outcomes and cost of warfarin therapy: a prospective study.

    Hughes, D., Jorgensen, A. L., Al-Zubiedi, S., Zhang, J. E., Keniry, A., Hanson, A., Hughes, D. A., Van Eker, D., Stevens, L., Hawkins, K., Toh, C. H., Kamali, F., Daly, A. K., Fitzmaurice, D., Coffey, A., Williamson, P. R., Park, B. K., Deloukas, P. & Pirmohamed, M., 1 Oct 2009, In: Pharmacogenetics and Genomics. 19, 10, p. 800-812

    Research output: Contribution to journal › Article › peer-review

24. Published

    HLA-B*5701 and abacavir hypersensitivity - Reply.

    Hughes, D., Hughes, D. A., Park, B. K. & Pirmohamed, M., 1 Nov 2004, In: Pharmacogenetics. 14, 11, p. 784

    Research output: Contribution to journal › Article › peer-review

25. Published

    HTAs and rare diseases: How to assess their cost-effectiveness

    Hughes, D., Phillips, C. J. & Hughes, D. A., 1 Nov 2011, In: Pharmaceuticals Policy and Law. 13, 3-4, p. 161-165

    Research output: Contribution to journal › Article › peer-review

26. Published

    Health utilities and costs for Motor Neurone Disease

    Moore, A., Young, C. A. & Hughes, D., Nov 2019, In: Value in Health. 22, 11, p. 1257-1265

    Research output: Contribution to journal › Article › peer-review

27. Published

    Health utilities and costs for neuromyelitis optica spectrum disorder

    Hughes, D., Bourke, S., Jones, A., Bhatt, R., Huda, S., Mutch, K. & Jacob, A., 2022, In: Orphanet Journal of Rare Diseases. 17, 11 p., 159.

    Research output: Contribution to journal › Article › peer-review

28. Published

    Health utilities and quality-adjusted life years for patients with amyotrophic lateral sclerosis receiving reldesemtiv or placebo in FORTITUDE-ALS

    Gebrehiwet, P., Meng, L., Saroccoa, P., Wei, J., Wolff, A. A., Butzner, M., Chio, A., Andrews, J. A., Genge, A., Hughes, D., Jackson, C. E., Lechtzin, N., Miller, T. M. & Shefner, J. M., 31 Mar 2023, In: Journal of Medical Economics. 26, 1, p. 488-493 6 p.

    Research output: Contribution to journal › Article › peer-review

29. Published

    Identification and Assessment of Adherence-Enhancing Interventions in Studies Assessing Medication Adherence Through Electronically Compiled Drug Dosing Histories: A Systematic Literature Review and Meta-Analysis

    Hughes, D., Holmes, E. A., Demonceau, J., Ruppar, T., Kristano, P., Hughes, A. D., Fargher, E., Przemyslaw, K., De Geest, S., Dobbels, F., Lewek, P., Urquhart, J. & Vrijens, B., 1 May 2013, In: Drugs. 73, 6, p. 545-562

    Research output: Contribution to journal › Article › peer-review

30. Published

    Impact of Interventions on Medication Adherence and Blood Pressure Control in Patients with Essential Hypertension: A Systematic Review by the ISPOR Medication Adherence and Persistence Special Interest Group

    Hughes, D., Gwadry-Sridhar, F. H., Manias, E., Lal, L., Salas, M., Hughes, D. A., Ratzki-Leewing, A. & Grubisic, M., 1 Jul 2013, In: Value in Health. 16, 5, p. 863-871

    Research output: Contribution to journal › Article › peer-review

31. Published

    Impact of non-adherence and flare resolution on the cost effectiveness of treatments for gout: Application of a linked pharmacometric/pharmacoeconomic model

    Hill-McManus, D., Marshall, S., Soto, E., Lane, S. & Hughes, D., Dec 2018, In: Value in Health. 21, 12, p. 1373-1381

    Research output: Contribution to journal › Article › peer-review

32. Published

    Impact of non-adherence on the safety and efficacy of uric acid lowering therapies in the treatment of gout

    Hill McManus, D., Soto, E., Marshall, S., Lane, S. & Hughes, D., Jan 2018, In: British Journal of Clinical Pharmacology. 84, 1, p. 142-152

    Research output: Contribution to journal › Article › peer-review

33. Published

    Impact of non-compliance on the cost-effectiveness of statin therapy

    Hughes, D., Hughes, D. A. & Bagust, A., 1 Sept 2001, In: Value in Health. 4, 6, p. 489

    Research output: Contribution to journal › Article › peer-review

34. Published

    Impact of relaxing Covid-19 social distancing measures on rural North Wales: a simulation analysis

    Hughes, R. P. & Hughes, D., 14 Dec 2020, In: Frontiers in Public Health. 8, 562473.

    Research output: Contribution to journal › Article › peer-review

35. Published

    Impact on the phased abolition of co-payments on the utilisation of selected prescription medicines in Wales

    Alam, M. F., Cohen, D., Dunstan, F., Hughes, D. & Routledge, P. A., Jan 2018, In: Health Economics. 27, 1, p. 236-243

    Research output: Contribution to journal › Article › peer-review

36. Published

    Impregnated central venous catheters for prevention of bloodstream infection in children (the CATCH trial): a randomised controlled trial

    Gilbert, R. E., Mok, Q., Dwan, K., Harron, K., Moitt, T., Millar, M., Ramnarayan, P., Tibby, S. M., Hughes, D. & Gamble, C. F., 23 Apr 2016, In: The Lancet. 387, 10029, p. 1732-1742

    Research output: Contribution to journal › Article › peer-review

37. Published

    Innovation at the Intersection of Clinical Trials and Real-World Data Science to Advance Patient Care

    Swift, B., Jain, L., White, C., Chandrasekaran, V., Bhandari, A., Hughes, D. & Jadhav, P., Sept 2018, In: Clinical and Translational Science. 11, 5, p. 450-460 11 p.

    Research output: Contribution to journal › Article › peer-review

38. Published

    Integration of Pharmacometrics and Pharmacoeconomics to Quantify the Value of Improved Forgiveness to Nonadherence: A Case Study of Novel Xanthine Oxidase Inhibitors for Gout

    Hill McManus, D., Marshall, S., Soto, E. & Hughes, D., Sept 2019, In: Clinical Pharmacology and Therapeutics. 106, 3, p. 652-660

    Research output: Contribution to journal › Article › peer-review

39. Published

    Interventions to improve osteoporosis medication adherence and persistence: a systematic review and literature appraisal by the ISPOR Medication Adherence & Persistence Special Interest Group

    Hughes, D., Linck, P. G., Hiligsmann, M., Salas, M., Hughes, D. A., Manias, E., Gwadry-Sridhar, F. H., Linck, P. & Cowell, W., 1 Dec 2013, In: Osteoporosis International. 24, 12, p. 2907-2918

    Research output: Contribution to journal › Article › peer-review

40. Published

    Is exercise effective in promoting mental well-being in older age? A systematic review.

    Hughes, D., Linck, P. G., Windle, G., Hughes, D. A., Linck, P., Russell, I. T. & Woods, R. T., 1 Aug 2010, In: Aging and Mental Health. 14, 6, p. 652-669

    Research output: Contribution to journal › Article › peer-review

41. Published

    Is there a role for Natural Desiccated Thyroid in the treatment of levothyroxine unresponsive hypothyroidism? Results from a Consecutive Case Series

    Heald, A., Premawardhana, L., Taylor, P., Okosieme, O., Bangi, T., Devine, H., Livingston, M., Javed, A., Moreno, G. Y. C., Watt, T., Stedman, M. & Hughes, D., 28 Dec 2021, In: International Journal of Clinical Practice. 75, 12, e14967.

    Research output: Contribution to journal › Article › peer-review

42. Published

    Lamotrigine versus levetiracetam or zonisamide for focal epilepsy and valproate versus levetiracetam for generalised and unclassified epilepsy: two SANAD II non-inferiority RCTs

    Marson, A. G., Burnside, G., Appleton, R., Smith, D., Leach, J. P., Sills, G., Tudor-Smith, C., Plumpton, C., Hughes, D., Williamson, P. R., Baker, G., Balabanova, S., Taylor, C., Brown, R., Hindley, D., Howell, S., Maguire, M., Mohanraj, R. & Smith, P. E., Dec 2021, In: Health Technology Assessment. 25, 75, 162 p.

    Research output: Contribution to journal › Article › peer-review

43. Published

    Less is more: Medicines that require less frequent administration improve adherence, but are they better?

    Hughes, D. & Hughes, D. A., 1 Jan 2006, In: Pharmacoeconomics. 24, 3, p. 211-213

    Research output: Contribution to journal › Article › peer-review

44. Published

    Lessons learnt from a discontinued randomised controlled trial: Adalimumab injection compared with placebo for patients receiving physiotherapy treatment for sciatica (Subcutaneous Injection of Adalimumab Trial compared with Control: SCIATiC)

    Williams, N., Jenkins, A., Goulden, N., Hoare, Z., Hughes, D., Wood, E., Foster, N. E., Walsh, D. A., Carnes, D., Sparkes, V., Hay, E. M., Isaacs, J., Konstantinou, K., Morrissey, D., Karppinen, J., Genevay, S. & Wilkinson, C., 31 Jul 2018, In: Trials. 19, 408.

    Research output: Contribution to journal › Article › peer-review

45. Published

    Linked Pharmacometric-Pharmacoeconomic Modeling and Simulation in Clinical Drug Development

    Hill-McManus, D., Marshall, S., Liu, J., Willke, R. & Hughes, D., Jul 2021, In: Clinical Pharmacology and Therapeutics. 110, 1, p. 49-63

    Research output: Contribution to journal › Article › peer-review

46. Published

    Liothyronine for hypothyroidism: A candidate for disinvestment or in need of further research? A value of information analysis

    Hughes, D., Skiadas, K., Fitzsimmons, D., Anderson, P. & Heald, A., 3 Dec 2021, In: BMJ Open. 11, 12, e051702.

    Research output: Contribution to journal › Article › peer-review

47. Published

    Managing Access to Advanced Therapy Medicinal Products: Challenges for NHS Wales

    Champion, A. R., Lewis, S., Davies, S. & Hughes, D., Jun 2021, In: British Journal of Clinical Pharmacology. 87, 6, p. 2444-2449

    Research output: Contribution to journal › Article › peer-review

48. Published

    Mapping ALSFRS-R and ALSUI to EQ-5D in patients with motor neurone disease

    Moore, A., Young, C. A. & Hughes, D., Nov 2018, In: Value in Health. 21, 11, p. 1322-1329

    Research output: Contribution to journal › Article › peer-review

49. Published

    Measurement of adherence, drug concentrations and the effectiveness of artemether-lumefantrine, chlorproguanil-dapsone or sulphadoxine-pyrimethamine in the treatment of uncomplicated malaria in Malawi.

    Hughes, D., Bell, D. J., Wootton, D., Mukaka, M., Montgomery, J., Kayange, N., Chimpeni, P., Hughes, D. A., Molyneux, M. E., Ward, S. A., Winstanley, P. A. & Lalloo, D. G., 26 Aug 2009, In: Malaria Journal. 8, p. 204

    Research output: Contribution to journal › Article › peer-review

50. Published

    Mechanism-Based Approach to the Economic Evaluation of Pharmaceuticals: Pharmacokinetic/Pharmacodynamic/Pharmacoeconomic Analysis of Rituximab for Follicular Lymphoma.

    Hughes, D., Pink, J., Lane, S. & Hughes, D. A., 19 Mar 2012, In: Pharmacoeconomics.

    Research output: Contribution to journal › Article › peer-review

51. Published

    Mechanistically informed non-invasive peripheral nerve stimulation for peripheral neuropathic pain: a randomised double-blind sham-controlled trial

    Johnson, S., Marshall, A., Hughes, D., Holmes, E., Henrich, F., Nurmikko, T., Sharma, M., Frank, B., Bassett, P., Marshall, A. & Goebel, A., 6 Nov 2021, In: Journal of Translational Medicine. 19, 1, 458.

    Research output: Contribution to journal › Article › peer-review