Professor Dyfrig Hughes

Athro mewn Ffarmacoeconomeg / Cyfarwyddwr Ymchwil

  1. Published

    Impact on the phased abolition of co-payments on the utilisation of selected prescription medicines in Wales

    Alam, M. F., Cohen, D., Dunstan, F., Hughes, D. & Routledge, P. A., Jan 2018, In: Health Economics. 27, 1, p. 236-243

    Research output: Contribution to journalArticlepeer-review

  2. Published

    Impregnated central venous catheters for prevention of bloodstream infection in children (the CATCH trial): a randomised controlled trial

    Gilbert, R. E., Mok, Q., Dwan, K., Harron, K., Moitt, T., Millar, M., Ramnarayan, P., Tibby, S. M., Hughes, D. & Gamble, C. F., 23 Apr 2016, In: The Lancet. 387, 10029, p. 1732-1742

    Research output: Contribution to journalArticlepeer-review

  3. Published

    Improving Medication Adherence Research Reporting: European Society for Patient Adherence, Compliance and Persistence Medication Adherence Reporting Guideline

    de Geest, S., Zullig, L., Dunbar-Jacobs, J., Hughes, D., Wilson, I. & Vrijens, B., Jun 2019, In: Journal of Cardiovascular Nursing. 34, 3, p. 199-200

    Research output: Contribution to journalEditorialpeer-review

  4. Published

    Improving Outcomes for People with Brain and Other CNS Tumours: Analysis of the Potential Economic Impact of the Guidance.

    Hughes, D., Linck, P., Priedane, E., Hughes, D. A. & Edwards, R. T., 1 Jan 2006, 2006 ed. Unknown.

    Research output: Book/ReportCommissioned report

  5. Published

    Improving Outcomes for People with Sarcoma: Analysis of the Potential Economic Impact of the Guidance.

    Hughes, D., Linck, P., Hughes, D. A. & Edwards, R. T., 1 Jan 2006, 2006 ed. Unknown.

    Research output: Book/ReportCommissioned report

  6. Published

    Improving Outcomes for People with Skin Tumours including Melanoma: Analysis of the Potential Economic Impact of the Guidance.

    Hughes, D., Linck, P., Hughes, D. A. & Edwards, R. T., 21 Feb 2006, Unknown.

    Research output: Book/ReportCommissioned report

  7. Published

    Improving Outcomes in Children and Young People with Cancer: Analysis of the Potential Economic Impact of the Guidance.

    Hughes, D., Linck, P., Tunnage, B., Hughes, D. A. & Edwards, R. T., 1 Jan 2005, 2005 ed. Unknown.

    Research output: Book/ReportCommissioned report

  8. Published

    Improving medication adherence research reporting: ESPACOMP Medication Adherence Reporting Guideline (EMERGE)

    de Geest, S., Zullig, L. L., Dunbar-Jacob, J., Hughes, D., Wilson, I. & Vrijens, B., 1 Apr 2019, In: European Journal of Cardiovascular Nursing. 18, 4, p. 258-259 2 p.

    Research output: Contribution to journalEditorialpeer-review

  9. Published

    Incorporating measures of compliance and persistence in pharmacoeconomic evaluations

    Hughes, D., Hughes, D. A. & Cowell, W., 1 Nov 2005.

    Research output: Contribution to conferencePaper

  10. Published

    Innovation at the Intersection of Clinical Trials and Real-World Data Science to Advance Patient Care

    Swift, B., Jain, L., White, C., Chandrasekaran, V., Bhandari, A., Hughes, D. & Jadhav, P., Sept 2018, In: Clinical and Translational Science. 11, 5, p. 450-460 11 p.

    Research output: Contribution to journalArticlepeer-review

  11. Published

    Integrating compliance and persistence in health economics models

    Hughes, D. & Hughes, D. A., 1 Jan 2008.

    Research output: Contribution to conferencePaper

  12. Published

    Integration of Pharmacometrics and Pharmacoeconomics to Quantify the Value of Improved Forgiveness to Nonadherence: A Case Study of Novel Xanthine Oxidase Inhibitors for Gout

    Hill McManus, D., Marshall, S., Soto, E. & Hughes, D., Sept 2019, In: Clinical Pharmacology and Therapeutics. 106, 3, p. 652-660

    Research output: Contribution to journalArticlepeer-review

  13. Published

    Internationalisation of cost-effectiveness model for on-demand use of proton pump inhibitors - Belgium.

    Hughes, D. & Hughes, D. A., 1 Jan 2004, 2004 ed. Unknown.

    Research output: Book/ReportCommissioned report

  14. Published

    Internationalisation of cost-effectiveness model for on-demand use of proton pump inhibitors - Sweden.

    Hughes, D. & Hughes, D. A., 1 Jan 2005, 2005 ed. Unknown.

    Research output: Book/ReportCommissioned report

  15. Published

    Interventions that enhance medication compliance and persistence: Theoretical grounding, and economic assessment

    Hughes, D., Hughes, D. A., Gwadry Sridhar, F., Elliott, R. & Cowell, W., 1 Oct 2007.

    Research output: Contribution to conferencePaper

  16. Published

    Interventions to improve osteoporosis medication adherence and persistence: a systematic review and literature appraisal by the ISPOR Medication Adherence & Persistence Special Interest Group

    Hughes, D., Linck, P. G., Hiligsmann, M., Salas, M., Hughes, D. A., Manias, E., Gwadry-Sridhar, F. H., Linck, P. & Cowell, W., 1 Dec 2013, In: Osteoporosis International. 24, 12, p. 2907-2918

    Research output: Contribution to journalArticlepeer-review

  17. Published

    Introduction to pharmaeconomics

    Hughes, D. & Hughes, D. A., 1 Jul 2004.

    Research output: Contribution to conferencePaper

  18. Published

    Investigating factors influencing user choices to visit either general practioners or community pharmacists in the management of minor ailments - piloting a discrete choice experiment.

    Hughes, D., Hughes, D. A., Myles, S., Longo, M. & Lisles, C., 1 Jan 2008, 2008 ed. Unknown.

    Research output: Book/ReportCommissioned report

  19. Published
  20. Published
  21. Published
  22. Published

    Involving colleagues can be challenging

    Fargher, E. & Hughes, D., 2 Apr 2011, In: Pharmaceutical Journal. 286, p. 404

    Research output: Contribution to journalLetterpeer-review

  23. Published

    Is exercise effective in promoting mental well-being in older age? A systematic review.

    Hughes, D., Linck, P. G., Windle, G., Hughes, D. A., Linck, P., Russell, I. T. & Woods, R. T., 1 Aug 2010, In: Aging and Mental Health. 14, 6, p. 652-669

    Research output: Contribution to journalArticlepeer-review

  24. Published

    Is there a role for Natural Desiccated Thyroid in the treatment of levothyroxine unresponsive hypothyroidism? Results from a Consecutive Case Series

    Heald, A., Premawardhana, L., Taylor, P., Okosieme, O., Bangi, T., Devine, H., Livingston, M., Javed, A., Moreno, G. Y. C., Watt, T., Stedman, M. & Hughes, D., 28 Dec 2021, In: International Journal of Clinical Practice. 75, 12, e14967.

    Research output: Contribution to journalArticlepeer-review

  25. Published

    Lamotrigine versus levetiracetam or zonisamide for focal epilepsy and valproate versus levetiracetam for generalised and unclassified epilepsy: two SANAD II non-inferiority RCTs

    Marson, A. G., Burnside, G., Appleton, R., Smith, D., Leach, J. P., Sills, G., Tudor-Smith, C., Plumpton, C., Hughes, D., Williamson, P. R., Baker, G., Balabanova, S., Taylor, C., Brown, R., Hindley, D., Howell, S., Maguire, M., Mohanraj, R. & Smith, P. E., Dec 2021, In: Health Technology Assessment. 25, 75, 162 p.

    Research output: Contribution to journalArticlepeer-review

  26. Published

    Less is more: Medicines that require less frequent administration improve adherence, but are they better?

    Hughes, D. & Hughes, D. A., 1 Jan 2006, In: Pharmacoeconomics. 24, 3, p. 211-213

    Research output: Contribution to journalArticlepeer-review

  27. Published

    Lessons learnt from a discontinued randomised controlled trial: Adalimumab injection compared with placebo for patients receiving physiotherapy treatment for sciatica (Subcutaneous Injection of Adalimumab Trial compared with Control: SCIATiC)

    Williams, N., Jenkins, A., Goulden, N., Hoare, Z., Hughes, D., Wood, E., Foster, N. E., Walsh, D. A., Carnes, D., Sparkes, V., Hay, E. M., Isaacs, J., Konstantinou, K., Morrissey, D., Karppinen, J., Genevay, S. & Wilkinson, C., 31 Jul 2018, In: Trials. 19, 408.

    Research output: Contribution to journalArticlepeer-review

  28. Published

    Letter to the Editor. Phase III randomized controlled trials are essential to properly evaluate the role of radiotherapy in WHO grade II meningioma

    Jenkinson, M., Weber, D., Haylock, B., Sherratt, F., Young, B., Weller, M., Bulbeck, H., Culeddu, G., Hughes, D., Brain, A., Das, K., Preusser, M., Francis, P. & Gamble, C., 17 Aug 2018, In: Journal of Neurology, Neurosurgery and Psychiatry.

    Research output: Contribution to journalLetterpeer-review

  29. Published

    Linked Pharmacometric-Pharmacoeconomic Modeling and Simulation in Clinical Drug Development

    Hill-McManus, D., Marshall, S., Liu, J., Willke, R. & Hughes, D., Jul 2021, In: Clinical Pharmacology and Therapeutics. 110, 1, p. 49-63

    Research output: Contribution to journalArticlepeer-review

  30. Published

    Liothyronine for hypothyroidism: A candidate for disinvestment or in need of further research? A value of information analysis

    Hughes, D., Skiadas, K., Fitzsimmons, D., Anderson, P. & Heald, A., 3 Dec 2021, In: BMJ Open. 11, 12, e051702.

    Research output: Contribution to journalArticlepeer-review

  31. Published

    Management of Patients Symptomatically Unresponsive to Levothyroxine: Natural Desiccated Thyroid Extract or the Combination of Levothyroxine and Liothyronine? A Research Priority

    Hughes, D., Livingston, M. & Heald, A., Sept 2020, In: Experimental and Clinical Endocrinology & Diabetes . 128, 9, p. 596-598

    Research output: Contribution to journalLetterpeer-review

  32. Published

    Managing Access to Advanced Therapy Medicinal Products: Challenges for NHS Wales

    Champion, A. R., Lewis, S., Davies, S. & Hughes, D., Jun 2021, In: British Journal of Clinical Pharmacology. 87, 6, p. 2444-2449

    Research output: Contribution to journalArticlepeer-review

  33. Published

    Mapping ALSFRS-R and ALSUI to EQ-5D in patients with motor neurone disease

    Moore, A., Young, C. A. & Hughes, D., Nov 2018, In: Value in Health. 21, 11, p. 1322-1329

    Research output: Contribution to journalArticlepeer-review

  34. Published

    Measurement of adherence, drug concentrations and the effectiveness of artemether-lumefantrine, chlorproguanil-dapsone or sulphadoxine-pyrimethamine in the treatment of uncomplicated malaria in Malawi.

    Hughes, D., Bell, D. J., Wootton, D., Mukaka, M., Montgomery, J., Kayange, N., Chimpeni, P., Hughes, D. A., Molyneux, M. E., Ward, S. A., Winstanley, P. A. & Lalloo, D. G., 26 Aug 2009, In: Malaria Journal. 8, p. 204

    Research output: Contribution to journalArticlepeer-review

  35. Published

    Mechanism-Based Approach to the Economic Evaluation of Pharmaceuticals: Pharmacokinetic/Pharmacodynamic/Pharmacoeconomic Analysis of Rituximab for Follicular Lymphoma.

    Hughes, D., Pink, J., Lane, S. & Hughes, D. A., 19 Mar 2012, In: Pharmacoeconomics.

    Research output: Contribution to journalArticlepeer-review

  36. Published

    Mechanistically informed non-invasive peripheral nerve stimulation for peripheral neuropathic pain: a randomised double-blind sham-controlled trial

    Johnson, S., Marshall, A., Hughes, D., Holmes, E., Henrich, F., Nurmikko, T., Sharma, M., Frank, B., Bassett, P., Marshall, A. & Goebel, A., 6 Nov 2021, In: Journal of Translational Medicine. 19, 1, 458.

    Research output: Contribution to journalArticlepeer-review

  37. Published

    Medication adherence research comes of age

    Wright, D. F. B., Sinnappah, K. A. & Hughes, D., Jul 2023, In: British Journal of Clinical Pharmacology. 89, 7, p. 1914-1917

    Research output: Contribution to journalEditorialpeer-review

  38. Published

    Medication adherence – key considerations for clinical pharmacologists

    Hughes, D., Apr 2020, In: British Journal of Clinical Pharmacology. 86, 4, p. 628-629 2 p.

    Research output: Contribution to journalEditorialpeer-review

  39. Published

    Medicines Shortages in the United Kingdom

    Hughes, D., Oct 2019, In: Clinical Pharmacology and Therapeutics. 106, 4, p. 712

    Research output: Contribution to journalLetterpeer-review

  40. Published

    Medicines concordance and game theory.

    Hughes, D. & Hughes, D. A., 1 Oct 2008, In: British Journal of Clinical Pharmacology. 66, 4, p. 577

    Research output: Contribution to journalArticlepeer-review

  41. Published

    Methodological Issues in the literature on costs of non-compliance in chronic diseases.

    Hughes, D., Salas, M., Zuluaga, A., Hughes, D. A., Cowell, W., Lebmeier, M., Vardeva, K., Pisu, M. & Shinogle, J., 1 Nov 2008, In: Value in Health. 11, 6, p. A571-A572

    Research output: Contribution to journalArticlepeer-review

  42. Published

    Methodological considerations on estimating medication adherence from self-report, electronic monitoring, and electronic healthcare databases using the TEOS framework

    Dima, A. L., Allemann, S. S., Dunbar-Jacob, J., Hughes, D., Vrijens, B. & Wilson, I., Jul 2023, In: British Journal of Clinical Pharmacology. 89, 7, p. 1918-1927

    Research output: Contribution to journalArticlepeer-review

  43. Published

    Methodological issues in the literature on costs of non-compliance in chronic diseases

    Hughes, D., Salas, M., Zuluaga, A., Hughes, D. A., Cowell, W., Lebmeie, M., Vardeva, K., Pisu, M. & Shinogle, J., 1 Nov 2008.

    Research output: Contribution to conferencePaper

  44. Published

    Methods for Extrapolating Survival Analyses for the Economic Evaluation of Advanced Therapy Medicinal Products

    Hardy, W. & Hughes, D., 16 Sept 2022, In: Human Gene Therapy. 33, 17-18, p. 845-856

    Research output: Contribution to journalArticlepeer-review

  45. Published

    Methods for integrating medication compliance and persistence in pharmacoeconomic evaluations.

    Hughes, D., Hughes, D. A., Cowell, W., Koncz, T. & Cramer, J., 1 Nov 2007, In: Value in Health. 10, 6, p. 498-509

    Research output: Contribution to journalArticlepeer-review

  46. Published

    Methods for the collection of resource use data within clinical trials: A systematic review of studies funded by the UK Health Technology Assessment Program

    Ridyard, C. H. & Hughes, D., 1 Dec 2010, In: Value in Health. 13, 8, p. 867-872

    Research output: Contribution to journalArticlepeer-review

  47. Published

    Microdiscectomy compared with transforaminal epidural steroid injection for persistent radicular pain caused by prolapsed intervertebral disc: the NERVES RCT

    Wilby, M. J., Best, A., Wood, E., Burnside, G., Bedson, E., Short, H., Wheatley, D., Hill-McManus, D., Sharma, M., Clark, S., Bostock, J., Hay, S., Baranidharan, G., Price, C., Mannion, R., Hutchinson, P. J., Hughes, D., Marson, A. & Williamson, P. R., Apr 2021, In: Health Technology Assessment. 25, 24, 86 p.

    Research output: Contribution to journalArticlepeer-review

  48. Published

    Modelling changes in first line antimalarial therapy

    Hughes, D. & Hughes, D. A., 1 Sept 2003.

    Research output: Contribution to conferencePaper

  49. Published

    Modelling in health economics

    Hughes, D., Hughes, D. A., Walley, T. (ed.), Haycox, A. (ed.), Boland, A. (ed.) & Breckenridge, A. (ed.), 1 Jan 2004, Pharmacoeconomics. 2004 ed. Adis International, p. 141-154

    Research output: Chapter in Book/Report/Conference proceedingChapter

  50. Published

    Multiple imputation of multiple multi-item scales when a full imputation model is infeasible

    Hughes, D., Plumpton, C. O., Morris, T., Hughes, D. A. & White, I. R., 26 Jan 2016, In: BMC Research Notes. 9, 45, p. 1-15

    Research output: Contribution to journalArticlepeer-review