Common variants in Alzheimer’s disease and risk stratification by polygenic risk scores

de Rojas, I., Moreno-Grau, S., Tesi, N., Grenier-Boley, B., Andrade, V., Jansen, I. E., Pedersen, N. L., Stringa, N., Zettergren, A., Hernández, I., Montrreal, L., Antúnez, C., Antonell, A., Tankard, R. M., Bis, J. C., Sims, R., Bellenguez, C., Quintela, I., González-Perez, A., Calero, M., Franco-Macías, E., Macías, J., Blesa, R., Cervera-Carles, L., Menéndez-González, M., Frank-García, A., Royo, J. L., Moreno, F., Huerto Vilas, R., Baquero, M., Diez-Fairen, M., Lage, C., García-Madrona, S., García-González, P., Alarcón-Martín, E., Valero, S., Sotolongo-Grau, O., Ullgren, A., Naj, A. C., Lemstra, A. W., Benaque, A., Pérez-Cordón, A., Benussi, A., Rábano, A., Padovani, A., Squassina, A., de Mendonça, A., Arias Pastor, A., Kok, A. A. L., Meggy, A., Pastor, A. B., Espinosa, A., Corma-Gómez, A., Martín Montes, A., Sanabria, Á., DeStefano, A. L., Schneider, A., Haapasalo, A., Kinhult Ståhlbom, A., Tybjærg-Hansen, A., Hartmann, A. M., Spottke, A., Corbatón-Anchuelo, A., Rongve, A., Borroni, B., Arosio, B., Nacmias, B., Nordestgaard, B. G., Kunkle, B. W., Charbonnier, C., Abdelnour, C., Masullo, C., Martínez Rodríguez, C., Muñoz-Fernandez, C., Dufouil, C., Graff, C., Ferreira, C. B., Chillotti, C., Reynolds, C. A., Fenoglio, C., Van Broeckhoven, C., Clark, C., Pisanu, C., Satizabal, C. L., Holmes, C., Buiza-Rueda, D., Aarsland, D., Rujescu, D., Alcolea, D., Galimberti, D., Wallon, D., Seripa, D., Grünblatt, E., Dardiotis, E., Düzel, E., Scarpini, E., Conti, E., Rubino, E., Gelpi, E., Rodriguez-Rodriguez, E., Duron, E., Boerwinkle, E., Ferri, E., Tagliavini, F., Küçükali, F., Pasquier, F., Sanchez-Garcia, F., Mangialasche, F., Jessen, F., Nicolas, G., Selbæk, G., Ortega, G., Chêne, G., Hadjigeorgiou, G., Rossi, G., Spalletta, G., Giaccone, G., Grande, G., Binetti, G., Papenberg, G., Hampel, H., Bailly, H., Zetterberg, H., Soininen, H., Karlsson, I. K., Alvarez, I., Appollonio, I., Giegling, I., Skoog, I., Saltvedt, I., Rainero, I., Rosas Allende, I., Hort, J., Diehl-Schmid, J., Van Dongen, J., Vidal, J-S., Lehtisalo, J., Wiltfang, J., Thomassen, J. Q., Kornhuber, J., Haines, J. L., Vogelgsang, J., Pineda, J. A., Fortea, J., Popp, J., Deckert, J., Buerger, K., Morgan, K., Fließbach, K., Sleegers, K., Molina-Porcel, L., Kilander, L., Weinhold, L., Farrer, L. A., Wang, L-S., Kleineidam, L., Farotti, L., Parnetti, L., Tremolizzo, L., Hausner, L., Benussi, L., Froelich, L., Ikram, M. A., Deniz-Naranjo, M. C., Tsolaki, M., Rosende-Roca, M., Löwenmark, M., Hulsman, M., Spallazzi, M., Pericak-Vance, M. A., Esiri, M., Bernal Sánchez-Arjona, M., Dalmasso, M. C., Martínez-Larrad, M. T., Arcaro, M., Nöthen, M. M., Fernández-Fuertes, M., Dichgans, M., Ingelsson, M., Herrmann, M. J., Scherer, M., Vyhnalek, M., Kosmidis, M. H., Yannakoulia, M., Schmid, M., Ewers, M., Heneka, M. T., Wagner, M., Scamosci, M., Kivipelto, M., Hiltunen, M., Zulaica, M., Alegret, M., Fornage, M., Roberto, N., van Schoor, N. M., Seidu, N. M., Banaj, N., Armstrong, N. J., Scarmeas, N., Scherbaum, N., Goldhardt, O., Hanon, O., Peters, O., Skrobot, O. A., Quenez, O., Lerch, O., Bossù, P., Caffarra, P., Dionigi Rossi, P., Sakka, P., Hoffmann, P., Holmans, P. A., Fischer, P., Riederer, P., Yang, Q., Marshall, R., Kalaria, R. N., Mayeux, R., Vandenberghe, R., Cecchetti, R., Ghidoni, R., Frikke-Schmidt, R., Sorbi, S., Hägg, S., Engelborghs, S., Helisalmi, S., Botne Sando, S., Kern, S., Archetti, S., Boschi, S., Fostinelli, S., Gil, S., Mendoza, S., Mead, S., Ciccone, S., Djurovic, S., Heilmann-Heimbach, S., Riedel-Heller, S., Kuulasmaa, T., del Ser, T., Lebouvier, T., Polak, T., Ngandu, T., Grimmer, T., Bessi, V., Escott-Price, V., Giedraitis, V., Deramecourt, V., Maier, W., Jian, X., Pijnenburg, Y. A. L., Smith, A. D., Saenz, A., Bizzarro, A., Lauria, A., Vacca, A., Solomon, A., Anastasiou, A., Richardson, A., Boland, A., Koivisto, A., Daniele, A., Greco, A., Marianthi, A., McGuinness, B., Fin, B., Ferrari, C., Custodero, C., Ferrarese, C., Ingino, C., Mangone, C., Reyes Toso, C., Martínez, C., Cuesta, C., Muchnik, C., Joachim, C., Ortiz, C., Besse, C., Johansson, C., Zoia, C. P., Laske, C., Anastasiou, C., Palacio, D. L., Politis, D. G., Janowitz, D., Craig, D., Mann, D. M., Neary, D., Jürgen, D., Daian, D., Belezhanska, D., Kohler, E., Castaño, E. M., Koutsouraki, E., Chipi, E., De Roeck, E., Costantini, E., Vardy, E. R. L. C., contributors, EADB., MacLeod, C., Woods, B. & Windle, G., 7 Jun 2021, In: Nature Communications. 12, 1, 3417.

Research output: Contribution to journal › Article › peer-review

Prevalence, New Incidence, Course, and Risk Factors of PTSD, Depression, Anxiety, and Panic Disorder during the Covid-19 Pandemic in 11 Countries

Georgieva, I., Lepping, P., Bozev, V., Lickiewicz, J., Pekara, J., Wikman, S., Loseviča, M., Raveesh, B. N., Mihai, A. & Lantta, T., 3 Jun 2021, In: Healthcare. 9, 6, 664.

Research output: Contribution to journal › Article › peer-review

Making personalised short breaks meaningful: a future research agenda to connect academia, policy and practice

Seddon, D., Miller, E., Prendergast, L., Williamson, D. & Cavaye, J., 2 Jun 2021, In: Quality in Ageing and Older Adults.

Research output: Contribution to journal › Article › peer-review

Acupuncture in the Management of Trigeminal Neuralgia

Edwards, J. & Shaw, V., 1 Jun 2021, In: Acupuncture in medicine : journal of the British Medical Acupuncture Society. 39, 3, p. 192-199 8 p.

Research output: Contribution to journal › Article › peer-review

A Systematic Review of Economic Evaluations of Advanced Therapy Medicinal Products

Lloyd Williams, H. & Hughes, D., Jun 2021, In: British Journal of Clinical Pharmacology. 87, 6, p. 2428-2443 16 p.

Research output: Contribution to journal › Review article › peer-review

A clinical librarian in a hospital critical care unit may generate a positive return on investment

Hartfiel, N., Sadera, G., Treadway, V., Lawrence, C. & Edwards, R. T., Jun 2021, In: Health Information and Libraries Journal. 38, 2, p. 97-112 16 p.

Research output: Contribution to journal › Article › peer-review

Can vital signs recorded in patients' homes aid decision making in emergency care? A Scoping Review

Hamza, M., Alsma, J., Kellett, J., Brabrand, M., Christensen, E. F., Cooksley, T., Haak, H. R., Nanayakkara, P. W. B., Merten, H., Schouten, B., Weichert, I. & Subbe, C. P., Jun 2021, In: Resuscitation plus. 6, 100116

Research output: Contribution to journal › Article › peer-review

Engaging and supporting women with chronic kidney disease with pre-conception decision-making (including their experiences during COVID 19): A mixed-methods study protocol

Phillips, R., McLaughlin, L., Williams, D., Williams, H., Noyes, J., Jones, C., Oleary, C., Mallett, C. & Griffin, S., Jun 2021, In: Journal of Advanced Nursing. 77, 6, p. 2887-2897 11 p.

Research output: Contribution to journal › Article › peer-review

Evaluation of a primary care-based collaborative care model (PARTNERS2) for people with diagnoses of schizophrenia, bipolar, or other psychoses: study protocol for a cluster randomised controlled trial

Plappert, H., Hobson-Merrett, C., Gibbons, B., Baker, E., Bevan, S., Clark, M., Creanor, S., Davies, L., Denyer, R., Frost, J., Gask, L., Gibson, J., Gill, L., Gwernan-Jones, R., Hardy, P., Hosking, J., Huxley, P., Jeffrey, A., Jones, B., Marwaha, S., Pinold, V., Planner, C., Rawcliffe, T., Reilly, S., Richards, D., Williams, L., Birchwood, M. & Byng, R., Jun 2021, In: BJGP open. 5, 3, 14 p.

Research output: Contribution to journal › Article › peer-review

Managing Access to Advanced Therapy Medicinal Products: Challenges for NHS Wales

Champion, A. R., Lewis, S., Davies, S. & Hughes, D., Jun 2021, In: British Journal of Clinical Pharmacology. 87, 6, p. 2444-2449

Research output: Contribution to journal › Article › peer-review

Schizophrenia outcomes in the 21st century: A systematic review

Huxley, P., Krayer, A., Poole, R., Prendergast, L., Aryal, S. & Warner, R., Jun 2021, In: Brain and behavior. 11, 6, 12 p., e02172.

Research output: Contribution to journal › Article › peer-review

TEOS: A framework for constructing operational definitions of medication adherence based on Timelines – Events – Objectives – Sources

Dima, A. L., Allemann, S. S., Dunbar-Jacobs, J., Hughes, D., Vrijens, B. & Wilson, I., Jun 2021, In: British Journal of Clinical Pharmacology. 87, 6, p. 2521-2533

Research output: Contribution to journal › Article › peer-review

Cost-effectiveness of home versus hospital management of children at onset of Type 1 Diabetes: The DECIDE randomised controlled trial

McCarroll, Z., Townson, J., Pickles, T., Gregory, J. W., Playle, R., Robling, M. & Hughes, D., 19 May 2021, In: BMJ Open. 11, 5, e043523.

Research output: Contribution to journal › Article › peer-review

Understanding what matters most to patients in acute care in seven countries, using the flash mob study design

van den Ende, E. S., Schouten, B., Kremers, M. N. T., Cooksley, T., Subbe, C. P., Weichert, I., van Galen, L. S., Haak, H. R., Kellett, J., Alsma, J., Siegrist, V., Holland, M., Christensen, E. F., Graham, C. A., Leung, L. Y., Laugesen, L. E., Merten, H., Mir, F., Kidney, R. M., Brabrand, M., Nanayakkara, P. W. B. & Nickel, C. H., 19 May 2021, In: BMC Health Services Research. 21, 1, 474.

Research output: Contribution to journal › Article › peer-review

Measles Outbreak Investigation Process in Low- and Middle-Income Countries (LMICs): A Systematic Review of the Methods and Costs of Contact Tracing

Mbivnjo, E. L., Lynch, M. & Huws, J., 15 May 2021, In: Journal of Public Health: From Theory to Practice. 20 p.

Research output: Contribution to journal › Article › peer-review

Surgical microdiscectomy versus transforaminal epidural steroid injection in patients with sciatica secondary to herniated lumbar disc (NERVES): a phase 3, multicentre, open-label, randomised controlled trial and economic evaluation

Wilby, M. J., Best, A., Wood, E., Burnside, G., Bedson, E., Short, H., Wheatley, D., Hill-McManus, D., Sharma, M., Clark, S., Baranidharan, G., Price, C., Mannion, R., Hutchinson, P. J., Hughes, D., Marson, A. G. & Williamson, P., 1 May 2021, In: The Lancet Rheumatology. 3, 5, p. e347-e356

Research output: Contribution to journal › Article › peer-review

The Impossible Clinic. A critical sociology of Evidence‐Based Medicine.

Jones, L., May 2021, In: Sociology of Health and Illness. 43, 4, p. 1073-1074

Research output: Contribution to journal › Book/Film/Article review › peer-review

The role of professional elites in healthcare governance: Exploring the work of the medical director

Jones, L. & Fulop, N., May 2021, In: Social Science and Medicine. 277, 113882.

Research output: Contribution to journal › Article › peer-review

The social determinants of mental health, the pandemic and social justice

Poole, R. & Nafees, S., May 2021, In: Arab Journal of Psychiatry. 32, 1, p. 16-20

Research output: Contribution to journal › Article › peer-review

Boundary organising in healthcare: theoretical perspectives, empirical insights and future prospects

Kislov, R., Harvey, G. & Jones, L., 27 Apr 2021, In: Journal of Health Organization and Management. 35, 2, p. 133-140

Research output: Contribution to journal › Article › peer-review

Community and Informal Care Providers at the Heart of Universal Health Coverage in sub-Saharan Africa: A Position Paper

Kisangala, E., Mbivnjo, E. L., Okeah, B. & Khan, M. A., 17 Apr 2021, In: South Eastern European Journal of Public Health. 18, Special Issue 2

Research output: Contribution to journal › Conference article › peer-review

The role of prevention in reducing the economic impact of ME/CFS in Europe: A report from the socioeconomics working group of the European Network on ME/CFS (EUROMENE).

Pheby, D. F. H., Araja, D., Berkis, U., Brenna, E., Cullinan, J., de Korwin, J-D., Gitto, L., Hughes, D., Hunter, R. M., Trépel, D. & Wang-Steverding, X., 16 Apr 2021, In: Medicina. 57, 4, 388.

Research output: Contribution to journal › Article › peer-review

Is it time to consign ‘anti-public health’ expressions to the dustbin of history?

Atenstaedt, R., 12 Apr 2021, In: Journal of Public Health. 43, 1, p. e119-e119

Research output: Contribution to journal › Article › peer-review

The SANAD II study of the effectiveness and cost-effectiveness of levetiracetam, zonisamide or lamotrigine for newly diagnosed focal epilepsy: an open-label, non-inferiority, multicentre, phase 4, randomised controlled trial

Marson, A., Burnside, G., Appleton, R., Smith, D., Leach, J. P., Sills, G., Tudor-Smith, C., Plumpton, C., Hughes, D., Williamson, P., Baker, G. A., Balabanova, S., Taylor, C., Brown, R., Hindley, D., Howell, S., Maguire, M., Mohanraj, R. & Smith, P. E., 10 Apr 2021, In: The Lancet. 397, 10282, p. 1363-1374

Research output: Contribution to journal › Article › peer-review

The SANAD II study of the effectiveness and cost-effectiveness of valproate versus levetiracetam for newly diagnosed generalised and unclassifiable epilepsy: an open-label, non-inferiority, multicentre, phase 4, randomised controlled trial

Marson, A., Burnside, G., Appleton, R., Leach, J. P., Sills, G., Tudor-Smith, C., Plumpton, C., Hughes, D., Williamson, P., Baker, G. A., Balabanova, S., Taylor, C., Brown, R., Hindley, D., Howell, S., Maguire, M., Mohanraj, R. & Smith, P. E., 10 Apr 2021, In: The Lancet. 397, 10282, p. 1375-1386

Research output: Contribution to journal › Article › peer-review

A Systematic Review to Examine the Evidence in Developing Social Prescribing Interventions That Apply a Co-Productive, Co-Designed Approach to Improve Well-Being Outcomes in a Community Setting

Thomas, G., Lynch, M. & Spencer, L., 8 Apr 2021, In: International Journal of Environmental Research and Public Health. 18, 8, 3896.

Research output: Contribution to journal › Article › peer-review

WASh multicentre randomised controlled trial: water-assisted sigmoidoscopy in English NHS bowel scope screening

Rutter, M., Evans, R., Hoare, Z., von Wagner, C., Deane, J., Esmally, S., Larkin, T., Edwards, R. T., Yeo, S. T., Spencer, L., Holmes, E., Saunders, B., Rees, C., Tsiamoulos, Z. & Beintaris, I., 7 Apr 2021, In: GUT . 70, 5, p. 845–852 8 p.

Research output: Contribution to journal › Article › peer-review

Measuring Quality of Life in Carers of People With Dementia: Development and Psychometric Evaluation of Scales measuring the Impact of DEmentia on CARers (SIDECAR)

Horton, M. C., Oyebode, J., Clare, L., Megson, M., Shearsmith, L., Brayne, C., Kind, P., Hoare, Z., Al Janabi, H., Hewison, V., Tennant, A. & Wright, P., 3 Apr 2021, In: Gerontologist. 61, 3, p. e1-e11

Research output: Contribution to journal › Article › peer-review

Content of Health Economics Analysis Plans (HEAPs) for trial-based economic evaluations: expert Delphi consensus survey

Thorn, J., Davies, C. F., Brookes, S., Noble, S., Dritsaki, M., Gray, E., Hughes, D., Mihaylova, B., Petrou, S., Ridyard, C., Sach, T., Wilson, E., Wordsworth, S. & Hollingworth, W., 1 Apr 2021, In: Value in Health. 24, 4, p. 539-547 9 p.

Research output: Contribution to journal › Article › peer-review

Evaluation of a framework for safe and appropriate prescribing of psychoactive medications in a UK prison

Bebbington, E., Lawson, J., Nafees, S., Robinson, C. & Poole, R., Apr 2021, In: Criminal Behaviour and Mental Health. 31, 2, p. 131-142

Research output: Contribution to journal › Article › peer-review

Microdiscectomy compared with transforaminal epidural steroid injection for persistent radicular pain caused by prolapsed intervertebral disc: the NERVES RCT

Wilby, M. J., Best, A., Wood, E., Burnside, G., Bedson, E., Short, H., Wheatley, D., Hill-McManus, D., Sharma, M., Clark, S., Bostock, J., Hay, S., Baranidharan, G., Price, C., Mannion, R., Hutchinson, P. J., Hughes, D., Marson, A. & Williamson, P. R., Apr 2021, In: Health Technology Assessment. 25, 24, 86 p.

Research output: Contribution to journal › Article › peer-review

Reversal of neurovascular coupling in the default mode network: Evidence from hypoxia

Rossetti, G., d'Avossa, G., Rogan, M., Macdonald, J., Oliver, S. & Mullins, P., Apr 2021, In: Journal of Cerebral Blood Flow and Metabolism. 41, 4, p. 805–818 14 p.

Research output: Contribution to journal › Article › peer-review

Re-purposing CORDIAL? Toward an effective treatment for depression in dementia

Woods, B., 30 Mar 2021, In: International psychogeriatrics. 33, 3, p. 195-197

Research output: Contribution to journal › Article › peer-review

Understanding the Global Challenges to Accessing Appropriate Wheelchairs: Position Paper

Gowran, R. J., Bray, N., Goldberg, M., Rushton, P., Barhouche Abou Saab, M., Constantine, D., Ghosh, R. & Pearlman, J., 24 Mar 2021, In: International Journal of Environmental Research and Public Health. 18, 7, 3338.

Research output: Contribution to journal › Article › peer-review

Cognitive impairment negatively impacts allied health service uptake: Investigating the association between health and service use.

MacLeod, C., Bu, F., Rutherford, A., Phillips, J., Woods, R. & CFAS-Wales research team, Mar 2021, In: SSM - Population Health . 13, 100720.

Research output: Contribution to journal › Article › peer-review

Electronic clinical decision support tool for assessing stomach symptoms in primary care (ECASS): a feasibility study

Rubin, G., Walter, F. M., Emery, J., Hamilton, W., Hoare, Z., Howse, J., Nixon, C., Srivastava, T., Thomas, C., Ukoumunne, O. C., Usher-Smith, J. A., Whyte, S. & Neal, R. D., Mar 2021, In: BMJ Open. 11, 3, e041795.

Research output: Contribution to journal › Article › peer-review

Embracing Change: Learnings From Implementing Multidimensional Digital Remote Monitoring in Oncology Patients at a District General Hospital During the COVID-19 Pandemic

Komarzynski, S., Wreglesworth, N. I., Griffiths, D., Pecchia, L., Subbe, C. P., Hughes, S. F., Davies, E. H. & Innominato, P. F., Mar 2021, In: JCO Clinical Cancer Informatics. 5, p. 216-220 5 p.

Research output: Contribution to journal › Comment/debate › peer-review

Status of primary and secondary mental healthcare of people with severe mental illness: an epidemiological study from the UK PARTNERS2 programme

Reilly, S., Marchevsky, N., Green, M., Davies, L., Plappert, H., Allard, J., Rawcliffe, T., Gibson, J., Clark, M., Pinfold, V., Gask, L., Huxley, P., Byng, R. & Birchwood, M., Mar 2021, In: British Journal of Psychiatry. 7, 2, e53.

Research output: Contribution to journal › Article › peer-review