A Framework for Planning and Critiquing Medication Compliance and Persistence Research Using Prospective Study Designs.

Hughes, D., Gwadry-Sridhar, F. H., Manias, E., Zhang, Y., Roy, A., Yu-Isenberg, K., Hughes, D. A. & Nichol, M. B., 1 Chwef 2009, Yn: Clinical Therapeutics. 31, 2, t. 421-435

Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid

A Fully Integrated Real-Time Detection, Diagnosis, and Control of Community Diarrheal Disease Clusters and Outbreaks (the INTEGRATE Project): Protocol for an Enhanced Surveillance System

McIntyre, K. M., Bolton, F. J., Christley, R. M., Cleary, P., Deja, E., Durie, A. E., Diggle, P. J., Hughes, D., de Lusignan, S., Orton, L., Radford, A. D., Elliot, A., Smith, G. E., Snape, D. A., Stanistreet, D., Vivancos, R., Winstanley, C. & O'Brien, S. J., 26 Medi 2019, Yn: JMIR Research Protocols. 8, 9, t. e13941 10 t., e13941.

Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid

A Global Survey of Antibiotic Leftovers in the Outpatient Setting.

Hughes, D., Kardas, P., Pechere, J. C., Hughes, D. A. & Cornaglia, G., 1 Rhag 2007, Yn: International Journal of Antimicrobial Agents. 30, 6, t. 530-536

Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid

A Literature Review of GP Knowledge and Understanding of ME/CFS: A Report from the Socioeconomics Working Group of the European Network on ME/CFS (EUROMENE)

Pheby, D. F. H., Araja, D., Berkis, U., Brenna, E., Cullinan, J., de Korwin, J.-D., Gitto, L., Hughes, D., Hunter, R. M., Trépel, D. & Wang-Steverding, X., Ion 2021, Yn: Medicina. 57, 1, 17 t., 7.

Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid

A Risk–Benefit Assessment of Prasugrel, Clopidogrel, and Genotype-Guided Therapy in Patients Undergoing Percutaneous Coronary Intervention

Hughes, D., Guzauskas, G. F., Hughes, D. A., Bradley, S. M. & Veenstra, D. L., 28 Maw 2012, Yn: Clinical Pharmacology and Therapeutics.

Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid

A framework for understanding sources of bias in medication adherence research

Sinnappah, K. A., Hughes, D., Stocker, S. L., Vrijens, B., Aronson, J. K. & Wright, D. F. B., Tach 2023, Yn: British Journal of Clinical Pharmacology. 89, 11, t. 3444-3453

Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid

A model-based cost-utility analysis of an automated notification system for deteriorating patients on general wards

Holmes, E., Hughes, D. & Subbe, C., 2 Mai 2024, Yn: PLoS ONE. 19, 5, t. e0301643 e0301643.

Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid

A new taxonomy for describing and defining adherence to medications

Holmes, E. A., Hughes, D., Morrison, V. L., Vrijens, B., De Geest, S., Hughes, D. A., Prezemyslaw, K., Demonceau, J., Ruppar, T., Dobbels, F., Fargher, E., Morrison, V., Lewek, P., Matyjaszczyk, M., Mshelia, C., Clyne, W., Aronson, J. K. & Urquhart, J., 1 Mai 2012, Yn: British Journal of Clinical Pharmacology. 73, 5, t. 691-705

Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid

A proposal for using benefit-risk methods to improve the prominence of adverse event results when reporting trials

Totton, N., Waddingham, E., Owen, R., Julious, S., Hughes, D. & Cook, J., 22 Meh 2024, Yn: Trials. 25, 409.

Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid

A randomised controlled trial of the clinical effectiveness, safety and cost-effectiveness of adalimumab in combination with methotrexate for the treatment of juvenile idiopathic arthritis associated uveitis (SYCAMORE Trial)

Hughes, D., Ramanan, A., Dick, A. D., Benton, D., Compeyrot-Lacassagne, S., Dawoud, D., Hardwick, B., Hickey, H., Hughes, D. A., Jones, A., Woo, P., Edelsten, C., Beresford, M. W. & The SYCAMORE Trail Management Group, [. V., 9 Ion 2014, Yn: Trials. 15, 14

Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid

A randomised, patient-assessor blinded, sham-controlled trial of external noninvasive peripheral nerve stimulation for chronic neuropathic pain following peripheral nerve injury (EN-PENS trial): study protocol for a randomised controlled trial

Johnson, S., Goebel, A., Richey, R., Holmes, E. & Hughes, D., 6 Rhag 2016, Yn: Trials. 17, 574.

Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid

A systematic review of cost–effectiveness analyses of pharmacogenetic-guided dosing in treatment with coumarin derivatives

Hughes, D., Verhoef, T. I., Redekop, W. K., Darba, J., Geitona, M., Hughes, D. A., Siebert, U., de Boer, A., Maitland-van der Zee, A. H., Barallon, R., Briz, M., Daly, A., Haschke-Becher, E., Kamali, F., Kirchheiner, J., Manolopoulos, V. G., Pirmohamed, M., Rosendaal, F. R., van Schie, R. M. & Wadelius, M., 1 Gorff 2010, Yn: Pharmacogenomics. 11, 7, t. 989-1002

Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid

A systematic review of economic evaluations of pharmacogenetic testing for prevention of adverse drug reactions

Plumpton, C. O., Roberts, D., Pirmohamed, M. & Hughes, D. A., Awst 2016, Yn: Pharmacoeconomics. 34, 8, t. 771-793

Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid

A systematic review of patients' perspectives on the subcutaneous route of medication administration

Ridyard, C., Dawoud, D. M., Tuersley, L. V. & Hughes, D., Awst 2016, Yn: Patient: Patient–Centered Outcomes Research. 9, 4, t. 281-292

Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid

A “Bundle of Care” to Improve Anticoagulation Control in Patients Receiving Warfarin in Uganda and South Africa: Protocol for an Implementation Study

Jorgensen, A., Waitt, C., Orrell, C., Cheng-Hock, T., Sekaggya-Wiltshire, C., Hughes, D., Allen, E., Okello, E., Tatz, G., Culeddu, G., Asiimwe, I. G., Semakula, J. R., Mouton, J. P., Cohen, K., Blockman, M., Lamorde, M. & Pirmohamed, M., 19 Gorff 2023, Yn: Journal of Medical Internet Research. 12, e46710.

Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid

Abacavir hypersensitivity: Is pre-prescription genotyping cost-effective?

Hughes, D., Hughes, D. A. & Pirmohamed, M., 1 Tach 2003, Yn: Value in Health. 6, 6, t. 749

Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid

Abolition of prescription charges in Wales: the impact on medicines use in those who used to pay

Hughes, D., Groves, S., Cohen, D., Alam, M. F., Dunstan, F. D., Routledge, P. A., Hughes, D. A. & Myles, S., 1 Rhag 2010, Yn: International Journal of Pharmacy Practice. 18, 6, t. 332-340

Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid

Abolition of prescription copayments in Wales: an observational study on dispensing rates.

Hughes, D., Cohen, D., Alam, M. F., Dunstan, F. D., Myles, S., Hughes, D. A. & Routledge, P. A., 1 Awst 2010, Yn: Value in Health. 13, 5, t. 675-680

Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid

Acceptability of generic versus innovator oral medicines: not only a matter of taste

Tuleu, C., Hughes, D., Clapham, D., Vallet, T. & Ruiz, F., Chwef 2021, Yn: Drug Discovery Today. 26, 2, t. 329-343

Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid

Accounting for non-compliance in pharmacoeconomic evaluations.

Hughes, D., Hughes, D. A., Bagust, A., Haycox, A. & Walley, T., 1 Ion 2001, Yn: Pharmacoeconomics. 19, 12, t. 1185-1197

Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid

Acute chloroquine poisoning: A comprehensive experimental toxicology assessment of the role of diazepam

Hughes, D., Tach 2020, Yn: British Journal of Pharmacology. 177, 21, t. 4975-4989 15 t.

Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid

Adalimumab in combination with methotrexate for refractory uveitis associated with juvenile idiopathic arthritis: a RCT

Ramanan, A. V., Dick, A. D., Jones, A. P., Hughes, D., McKay, A., Rosala_Hanna, A., Williamson, P. R., Hardwick, B., Hickey, H., Rainford, N., Kolamunnage-Dona, R., Culeddu, G., Plumpton, C., Wood, E., Compeyrot-Lacassagne, S., Woo, P., Eldesten, C. & Beresford, M. W., 10 Ebr 2019, Yn: Health Technology Assessment. 23, 15, t. 1-174 174 t.

Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid

Adalimumab plus Methotrexate for Uveitis in Juvenile Idiopathic Arthritis

Ramanan, A. V., Dick, A. D., Jones, A. P., McKay, A., Williamson, P. R., Compeyrot-Lacassagne, S., Hardwick, B., Hickey, H., Hughes, D., Woo, P., Benton, D., Edelsten, C. & Beresford, M. W., 27 Ebr 2017, Yn: New England Journal of Medicine. 376, 17, t. 1637-1646

Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid

Adherence and variability in warfarin dose requirements: assessment in a prospective cohort

Hughes, D., Jorgensen, A. L., Hughes, D. A., Hanson, A., van Eker, D., Toh, C. H., Pirmohamed, M. & Williamson, P. R., 1 Ion 2013, Yn: Pharmacogenomics. 14, 2, t. 151-163

Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid

Adherence of patients to long-term medication: a cross-sectional study of antihypertensive regimens in Austria

Lotsch, F., Auer-Hackenberg, L., Groger, M., Rehman, K., Morrison, V. L., Holmes, E. A., Parveen, S., Plumpton, C. O., Clyne, W., de Geest, S., Dobbels, F., Vrijens, B., Kardas, P., Hughes, D. & Ramharter, M., Mai 2015, Yn: Wiener klinische Wochenschrift. 127, 9-10, t. 379-384

Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid

Advanced therapy medicinal products: a comprehensive overview for pharmacy professionals

McKenzie, C. A., Chappel, J., Guy, R. H., Hawksworth, G., Hughes, D. & Black, A., 12 Awst 2022, Yn: Pharmaceutical Journal.

Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid

Adverse drug reactions in economic evaluations

Hughes, D. & Hughes, D. A., 1 Ion 2007, Yn: Value in Health. 10, 3, t. A109

Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid

Adverse drug reactions, multimorbidity and polypharmacy: A prospective analysis of one month of medical admissions

Osanlou, R., Walker, L., Hughes, D., Burnside, G. & Pirmohamed, M., 4 Gorff 2022, Yn: BMJ Open. 12, 7, e055551.

Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid

Affordable orphan drugs: A role for not-for-profit organisations

Davies, E. H., Fulton, E., Brook, D. & Hughes, D., Gorff 2017, Yn: British Journal of Clinical Pharmacology. 83, 7, t. 1595-1601

Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid

An agenda for UK clinical pharmacology Pharmacoeconomics

Hughes, D. & Hughes, D. A., 1 Meh 2012, Yn: British Journal of Clinical Pharmacology. 73, 6, t. 968-972

Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid

An explanatory randomised controlled trial of a nurse-led, consultation-based intervention to support patients with adherence to taking glucose lowering medication for type 2 diabetes

Hughes, D., Farmer, A., Hardeman, W., Hughes, D. A., Prevost, A. T., Kim, Y., Craven, A., Oke, J., Boase, S., Selwood, M., Kellar, I., Graffy, J., Griffin, S., Sutton, S. & Kinmonth, A. L., 5 Ebr 2012, Yn: BMC Family Practice. 13, 30

Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid

Antibiotic or silver versus standard ventriculoperitoneal shunts (BASICS): a multi-centre, single-blinded, randomised trial and economic evaluation

Mallucci, C. L., Jenkinson, M. D., Conroy, E. J., Hartley, J. C., Brown, M., Dalton, J., Kearns, T., Moitt, T., Griffiths, M. J., Culeddu, G., Solomon, T., Hughes, D. & Gamble, C., 26 Hyd 2019, Yn: The Lancet. 394, 10208, t. 1530-1539 10 t.

Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid

Appropriate design and reporting of superiority, equivalence and non-inferiority clinical trials incorporating a benefit risk assessment: the BRAINS study including expert workshop

Totton, N., Julious, S., Coates, E., Hughes, D., Cook, J., Biggs, K., Hewitt, C., Day, S. & Cooke, A., Hyd 2023, Yn: Health Technology Assessment. 27, 20, 86 t.

Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid

Assessing the association between compliance and therapeutic failure for antiretroviral drugs in HIV positive patients

Hughes, D. & Hughes, D. A., 1 Ion 2007, Yn: Value in Health. 10, 3, t. A171

Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid

Best step-up treatments for children with uncontrolled asthma: A systematic review and network meta-analysis of individual participant data

Cividini, S., Sinha, I., Donegan, S., Maden, M., Rose, K., Fulton, O., Culeddu, G., Hughes, D., Turner, S. & Tudor-Smith, C., 21 Rhag 2023, Yn: European Respiratory Journal. 62, 6, 2301011.

Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid

Between- and within-individual sociodemographic and psychological determinants of PrEP adherence among men who have sex with men prescribed a daily PrEP regimen in Wales

Gillespie, D., de Bruin, M., Hughes, D., Ma, R., Williams, A., Wood, F., Couzens, Z., Jones, A. T. & Hood, K., Mai 2023, Yn: AIDS and Behavior. 27, 5, t. 1564-1572 9 t.

Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid

Beyond registration: measuring the public health potential of new treatments for Malaria in Africa.

Hughes, D., Lang, T., Hughes, D. A., Kanyok, T., Kengeya-Kayondo, J., Marsh, V., Haaland, A., Pirmohamed, M. & Winstanley, P., 1 Ion 2006, Yn: Lancet Infectious Diseases. 6, 1, t. 46-52

Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid

Biological agents for the management of Crohn's disease in adults: A systematic review, meta-analysis and multiples treatment comparison

Hughes, D., Hughes, D. A., Kikuchi, T. & Bodger, K., 1 Ion 2007, Yn: Value in Health. 10, 3, t. A147

Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid

Biosimilars: Evidential standards for health technology assessment.

Hughes, D. & Hughes, D. A., 1 Maw 2010, Yn: Clinical Pharmacology and Therapeutics. 87, 3, t. 257-261

Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid

CARer-ADministration of as-needed subcutaneous medication for breakthrough symptoms in homebased dying patients (CARiAD): study protocol for a UK-based open randomised pilot trial

Poolman, M., Roberts, J., Byrne, A., Perkins, P., Hoare, Z., Nelson, A., Hiscock, J., Hughes, D., Foster, B., O'Connor, J., Reymond, L., Healy, S., Roberts, R., Wee, B., Lewis, P., Johnstone, R., Roberts, S., Holmes, E., Wright, S., Hendry, A. & Wilkinson, C., 7 Chwef 2019, Yn: Trials. 20, 1, 16 t., 105.

Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid

CATheter Infections in CHildren (CATCH): a randomised controlled trial and economic evaluation comparing impregnated and standard central venous catheters in children

Harron, K., Mok, Q., Dwan, K., Ridyard, C., Mott, T., Millar, M., Ramnarayan, P., Tibby, S. M., Muller-Pebody, B., Hughes, D., Gamble, C. & Gilbert, R. E., Maw 2016, Yn: Health Technology Assessment. 20, 18

Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid

Carer administration of as-needed sub-cutaneous medication for breakthrough symptoms in people dying at home: the CARiAD feasibility RCT

Poolman, M., Roberts, J., Wright, S., Hendry, A., Goulden, N., Holmes, E., Byrne, A., Perkins, P., Hoare, Z., Nelson, A., Hiscock, J., Hughes, D., O'Connor, J., Foster, B., Reymond, L., Healy, S., Lewis, P., Wee, B., Johnstone, R. P., Roberts, R., Parkinson, A., Roberts, S. & Wilkinson, C., 2 Meh 2020, Yn: Health Technology Assessment. 24, 25, 150 t.

Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid

Challenges in the Development and Reimbursement of Personalized Medicine—Payer and Manufacturer Perspectives and Implications for Health Economics and Outcomes Research: A Report of the ISPOR Personalized Medicine Special Interest Group

Hughes, D., Faulkner, E., Annemans, L., Garrison, L., Helfand, M., Holtorf, A. P., Hornberger, J., Hughes, D. A., Li, T., Malone, D., Payne, K., Siebert, U., Towse, A., Veenstra, D. & Watkins, J., 1 Rhag 2012, Yn: Value in Health. 15, 8, t. 1162-1171

Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid

Changing Agendas on Sleep, Treatment and Learning in Epilepsy (CASTLE) Sleep-E: A protocol for a randomised controlled trial comparing an online behavioural sleep intervention with standard care in children with Rolandic epilepsy

Al-Najjar, N., Bray, L., Carter, B., Collingwood, A., Cook, G., Crudgington, H., Dietz, K., Hardy, W., Hiscock, H., Hughes, D., Morris, C., Rouncefield-Swales , A., Saron, H., Spowart, C., Stibbs-Easton, L., Tudur Smith, C., Watson, V., Whittle, L., Wiggs, L., Wood, E., Gringas, P. & Pal, D. K., 10 Maw 2023, Yn: BMJ Open. 13, 3, e065769.

Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid

Charitable contributions to funding cancer services for children and young people in England and Wales

Hughes, D., Linck, P., Tunnage, B., Hughes, D. A. & Edwards, R. T., 1 Ion 2008, Yn: Journal of Child Health Care. 12, 2, t. 156-168

Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid

Chiral chromatography: Costs of chiral switching.

Hughes, D. & Hughes, D. A., 1 Ion 2008, Yn: Pharmaceutical Journal. 281, t. 213

Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid

Choice of oral anticoagulant prescribed by general practices in Wales: Application of Dirichlet regression and linked data

Hill-McManus, D. & Hughes, D., Meh 2022, Yn: British Journal of Clinical Pharmacology. 88, 6, t. 2782-2792 11 t.

Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid

Cisplatin plus vinorelbine or gemcitabine in patients with advanced non-small cell lung cancer: Pharmacoeconomic considerations.

Hughes, D. & Hughes, D. A., 1 Gorff 2005, Yn: European Journal of Cancer. 41, 11, t. 1655

Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid

Climate influences on the cost-effectiveness of vector-based interventions against malaria in elimination scenarios

Hughes, D., Parham, P. E. & Hughes, D. A., 16 Chwef 2015, Yn: Philosophical Transactions B: Biological Sciences. 370, 1665

Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid

Clinical Pharmacology: Special safety considerations in drug development and pharmacovigilance.

Hughes, D., Atuah, K. N., Hughes, D. A. & Pirmohamed, M., 1 Ion 2004, Yn: Drug Safety. 27, 8, t. 535-554

Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid