Research Portal

Dr Ramsay Mcfarlane

Senior Lecturer in Biomedical Sciences (Medical & Molecular Genetics)

Affiliations

ORCID: 0000-0002-3139-3092

Contact info

Location: Brambell, Room 405

Phone: 2360

Email: r.macfarlane@bangor.ac.uk

Position: Senior Lecturer / Research Group Leader / Deputy Head of School – Research

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  1. Article › Research › Peer-reviewed
  2. Published

    5-azacytidine treatment of the fission yeast leads to cytotxicity and cell cycle arrest.

    Taylor, E. M., Mcfarlane, R. & Price, C., 1996, In: Molecular Genetics and Genomics. 253, 1-2, p. 128-137

    Research output: Contribution to journal › Article › peer-review

  3. Published

    A novel cohort of cancer-testis biomarker genes revealed through meta-analysis of clinical data sets

    Sammut, S. J., Feichtinger, J., Stuart, N. S., Wakeman, J., Larcombe, L. & Mcfarlane, R. J., 6 May 2014, In: Oncoscience. 1, 5, p. 349-359

    Research output: Contribution to journal › Article › peer-review

  4. Published

    A role for recombination in centromere function.

    Mcfarlane, R. J., McFarlane, R. J. & Humphrey, T. C., 1 May 2010, In: Trends in Genetics. 26, 5, p. 209-213

    Research output: Contribution to journal › Article › peer-review

  5. Published

    Biological roles of translin and translin-associated factor-X: RNA metabolism comes to the fore.

    Mcfarlane, R. J., Jaendling, A. & McFarlane, R. J., 15 Jul 2010, In: Biochemical Journal. 429, 2, p. 225-234

    Research output: Contribution to journal › Article › peer-review

  6. Published

    Brachyury identifies a class of enteroendocrine cells in normal human intestinal crypts and colorectal cancer

    Jezkova, J., Williams, J. S., Pinto, F., Sammut, S. J., Williams, G. T., Gollins, S., Mcfarlane, R. J., Reis, R. M. & Wakeman, J., 5 Feb 2016, In: Oncotarget. 2016, 7, p. 11478-11486

    Research output: Contribution to journal › Article › peer-review

  7. Published

    Brachyury regulates proliferation of cancer cells via a p27Kip1-dependent pathway

    Mcfarlane, R. J., Gollins, S. W., Wakeman, J., Jezkova, J., Williams, J. S., Jones-Hutchins, F., Sammut, S. J., Gollins, S., Cree, I., Coupland, S., McFarlane, R. J. & Wakeman, J. A., 21 May 2014, In: Oncotarget. 5, 11, p. 3813-3822

    Research output: Contribution to journal › Article › peer-review

  8. Published

    Brachyury: Strategies for Drugging an Intractable Cancer Therapeutic Target

    Robinson, H., McFarlane, R. J. & Wakeman, J. A., Apr 2020, In: Trends in cancer. 6, 4, p. 271-273 3 p.

    Research output: Contribution to journal › Article › peer-review

  9. Published

    Cancer germline gene activation: Friend or foe?

    Mcfarlane, R. J., McFarlane, R. J., Feichtinger, J. & Larcombe, L., 23 Jun 2014, In: Cell Cycle. 13, 14, p. 2151-2152

    Research output: Contribution to journal › Article › peer-review

  10. Published

    Cancer/Testis Antigens and Colorectal Cancer

    Sammut, S. J., Wakeman, J., Mcfarlane, R. J., Sammut, J., Wakeman, J. A., Stuart, N. & McFarlane, R. J., 13 Jun 2013, In: Journal of Genetic Syndromes and Gene Therapy. 4, 5, p. 149

    Research output: Contribution to journal › Article › peer-review

  11. Published

    CancerEST: a web-based tool for automatic meta-analysis of public EST data

    Mcfarlane, R. J., Feichtinger, J., McFarlane, R. J. & Larcombe, L. D., 27 Feb 2014, In: Database: The Journal of Biological Databases and Curation. 2014

    Research output: Contribution to journal › Article › peer-review

  12. Published

    CancerMA: a web-based tool for automatic meta-analysis of public cancer microarray data.

    Feichtinger, J., Mcfarlane, R. & Larcombe, L., 15 Dec 2012, In: Database: The Journal of Biological Databases and Curation. 2012, bas055.

    Research output: Contribution to journal › Article › peer-review

  13. Published

    Characterisation of the Schizosaccharomyces pombe rad4/cut5 mutant phenotypes: dissection of DNA replication and G2 checkpoint control function.

    Mcfarlane, R., Carr, A. M. & Price, C., 1 Jul 1997, In: Molecular Genetics and Genomics. 255, 3, p. 332-340

    Research output: Contribution to journal › Article › peer-review

  14. Published

    Comparative proteomic analysis reveals differential expression of Hsp25 following the directed differentiation of mouse embryonic stem cells.

    Wakeman, J., Mcfarlane, R. J., Battersby, A., Jones, R. D., Lilley, K. S., McFarlane, R. J., Braig, H. R., Allen, N. D. & Wakeman, J. A., 1 Feb 2007, In: Biochimica et Biophysica Acta - Molecular Cell Research. 1773, 2, p. 147-156

    Research output: Contribution to journal › Article › peer-review

  15. Published

    Differential activation of M26-containing meiotic recombination hot spots in Schizosaccharomyces pombe.

    Mcfarlane, R. J., Pryce, D. W., Lorenz, A., Smirnova, J. B., Loidl, J. & McFarlane, R. J., 1 May 2005, In: Genetics. 170, 1, p. 95-106

    Research output: Contribution to journal › Article › peer-review

  16. Published

    Functional characterisation of the Schizosaccharomyces pombe homologue of the leukaemia-associated translocation breakpoint binding protein translin and its binding partner, TRAX.

    Mcfarlane, R. J., Jaendling, A., Ramayah, S., Pryce, D. W. & McFarlane, R. J., 1 Feb 2008, In: Biochimica et Biophysica Acta - Molecular Cell Research. 1783, 2, p. 203-213

    Research output: Contribution to journal › Article › peer-review

  17. Published

    Germline/meiotic genes in cancer: new dimensions

    Mcfarlane, R. J., McFarlane, R. J., Feichtinger, J. & Larcombe, L., 19 Mar 2015, In: Cell Cycle. 14, 6, p. 791-792

    Research output: Contribution to journal › Article › peer-review

  18. Published

    Homologous chromosome pairing in Schizosaccharomyces pombe

    Mcfarlane, R. J., Wells, J. L., Pryce, D. W. & McFarlane, R. J., 15 Oct 2006, In: Yeast. 23, 13, p. 977-989

    Research output: Contribution to journal › Article › peer-review

  19. Published

    Human germ/stem cell-specific gene TEX19 influences cancer cell proliferation and cancer prognosis

    Planells Palop, V., Hazazi, A., Feichtinger, J., Jezkova, J., Thallinger, G. G., Alsiwiehri, N., Almutairi, M., Parry, L., Wakeman, J. & Mcfarlane, R., 26 Apr 2017, In: Molecular Cancer. 16, 1, p. 1-18 84.

    Research output: Contribution to journal › Article › peer-review

  20. Published

    Identification of a class of human cancer germline genes with transcriptional silencing refractory to the hypomethylating drug 5-aza-2'-deoxycytidine

    Almatrafi, A., Feichtinger, J., Vernon, E. G., Escobar, N. G., Wakeman, J. A., Larcombe, L. D. & McFarlane, R. J., 10 Nov 2014, In: Oncoscience. 1, 11, p. 745-750 6 p.

    Research output: Contribution to journal › Article › peer-review

  21. Published

    Linear element-independent meiotic recombination in Schizosaccharomyces pombe.

    Mcfarlane, R. J., Wells, J. L., Pryce, D. W., Estreicher, A., Loidl, J. & McFarlane, R. J., 1 Nov 2006, In: Genetics. 174, 3, p. 1105-1114

    Research output: Contribution to journal › Article › peer-review

  22. Published

    Meiosis-like functions in oncogenesis: a new view of cancer.

    Mcfarlane, R. & Wakeman, J., Nov 2017, In: Cancer Research. 77, 21, p. 5712-5716

    Research output: Contribution to journal › Article › peer-review

  23. Published

    Meiotic gene activation in somatic and germ cell tumours

    Mcfarlane, R. & Feichtinger, J., Jul 2019, In: Andrology. 7, 4, p. 415-427 13 p.

    Research output: Contribution to journal › Article › peer-review

  24. Published

    Meta-analysis of cancer microarray data sets reveals a germ line expression profile in ovarian cancers: new biomarkers and potential drug targets

    Mcfarlane, R. J. & McFarlane, R., 15 Aug 2015, In: Clinical Cancer Research. 21, 16

    Research output: Contribution to journal › Article › peer-review

  25. Published

    Meta-analysis of clinical data using human meiotic genes identifies a novel cohort of highly restricted cancer-specific marker genes.

    Stuart, N. S., Wakeman, J., Mcfarlane, R. J., Feichtinger, J., Aldeailej, I., Anderson, R., Almutairi, M., Almatrafi, A., Alsiwiehri, N., Griffiths, K., Stuart, N., Wakeman, J. A., Larcombe, L. & McFarlane, R. J., 13 Aug 2012, In: Oncotarget. 3, 8, p. 843-853

    Research output: Contribution to journal › Article › peer-review

  26. Published

    Meta-analysis of expression of l(3)mbt tumor-associated germline genes supports the model that a soma-to-germline transition is a hallmark of human cancers

    Mcfarlane, R. J., Feichtinger, J., Larcombe, L. & McFarlane, [. V., 15 May 2014, In: International Journal of Cancer. 134, 10, p. 2359-2365

    Research output: Contribution to journal › Article › peer-review

  27. Published

    Modification of bacterial artificial chromosomes through chi-stimulated homologous recombination and its application in zebrafish transgenesis.

    Jessen, J. R., Meng, A., Mcfarlane, R., Paw, B. H., Zon, L. I., Smith, G. R. & Lin, S., 1998, In: Proceedings of the National Academy of Sciences of the USA. 95, 9, p. 5121 5126 p.

    Research output: Contribution to journal › Article › peer-review

  28. Published
  29. Published

    Psc3 cohesion of Schizosaccharomyces pombe: cell cycle analysis and identification of three distinct isoforms

    Ilyushik, E., Pryce, D., Walerych, D., Riddell, T., Wakeman, J. A., McInerny, C. J. & Mcfarlane, R., Jul 2005, In: Biological Chemistry. 386, 7, p. 613-621

    Research output: Contribution to journal › Article › peer-review

  30. Published

    Recombination at DNA replication fork barriers is not universal and is differentially regulated by Swi1

    Pryce, D. W., Ramayah, S., Jaendling, A. & Mcfarlane, R., 24 Mar 2009, In: Proceedings of the National Academy of Sciences of the USA. 106, 12, p. 4770-4775

    Research output: Contribution to journal › Article › peer-review

  31. Published

    S-pombe meiotic linear elements contain proteins related to synaptonemal complex components

    Lorenz, A., Wells, J. L., Pryce, D., Novatchkova, M., Eisenhaber, F., Mcfarlane, R. J. & Loidl, J., 28 Jun 2004, In: Journal of Cell Science. 117, 15, p. 3343-3351

    Research output: Contribution to journal › Article › peer-review

  32. Published

    SUMOylation is required for normal development of linear elements and wild-type meiotic recombination in Schizosaccharomyces pombe.

    Mcfarlane, R. J., Spirek, M., Estreicher, A., Csaszar, E., Wells, J., McFarlane, R. J., Watts, F. Z. & Loidl, J., 1 Feb 2010, In: Chromosoma. 119, 1, p. 59-72

    Research output: Contribution to journal › Article › peer-review

  33. Published

    The Meiotic Recombination Hotspots of Schizosaccharomyces pombe

    Pryce, D. & Mcfarlane, R. J., 1 Jan 2009, In: Meiosis. 5, p. 1-13

    Research output: Contribution to journal › Article › peer-review

  34. Published

    The genetics of the repaor of 5-azacytidine-mediated DNA damage in the fission yeast Schizosaccharomyces pombe.

    Hegde, V., Mcfarlane, R., Taylor, E. M. & Price, C., 1 Jun 1996, In: Molecular Genetics and Genomics. 251, 4, p. 483-492

    Research output: Contribution to journal › Article › peer-review

  35. Published

    The immortal strand hypothesis: still non-randomly segregating opinion.

    Wakeman, J., Hmadcha, A., Soria, B. & Mcfarlane, R., 23 Mar 2012, In: Biomolecular Concepts. 3, 3, p. 203-211

    Research output: Contribution to journal › Article › peer-review

  36. Published

    The many facets of the Tim-Tipin protein families' roles in chromosome biology.

    Mcfarlane, R. J., McFarlane, R. J., Mian, S. & Dalgaard, J. Z., 15 Feb 2010, In: Cell Cycle. 9, 4, p. 700-705

    Research output: Contribution to journal › Article › peer-review

  37. Published

    The unique centromeric chromatin structure of Schizosaccharomyces pombe is maintained during meiosis.

    Mcfarlane, R. J., Smirnova, J. B. & McFarlane, R. J., 31 May 2002, In: Journal of Biological Chemistry. 277, 22, p. 19817-19822

    Research output: Contribution to journal › Article › peer-review

  38. Published

    Translin and Trax differentially regulate telomere-associated transcript homeostasis

    Gomez Escobar, N., Almobadel, N., Alzahrani, O., Feichtinger, J., Planells Palop, V., Alshehri, Z., Thallinger, G. G., Wakeman, J. & Mcfarlane, R., 10 May 2016, In: Oncotarget. 12 p.

    Research output: Contribution to journal › Article › peer-review

  39. Published

    Translin facilitates RNA polymerase II dissociation and suppresses genome instability during RNase H2- and Dicer-deficiency

    Gomez Escobar, N., Alsaiari, A., Alahmadi, H. A. S., Alzahrani, O., Vernon, E., Althagafi, H., Almobadel, N., Pryce, D., Wakeman, J. & Mcfarlane, R., 17 Jun 2022, In: PLOS Genetics. 18, 6, e1010267.

    Research output: Contribution to journal › Article › peer-review

  40. Published

    Translin-Trax: Considerations for Oncological Therapeutic Targeting

    McFarlane, R. J. & Wakeman, J. A., Jun 2020, In: Trends in Cancer. 6, 6, p. 450-453 4 p.

    Research output: Contribution to journal › Article › peer-review

  41. Published

    tRNA genes in eukaryotic genome organization and reorganization.

    Mcfarlane, R. J., McFarlane, R. J. & Whitehall, S. K., 1 Oct 2009, In: Cell Cycle. 8, 19, p. 3102-3106

    Research output: Contribution to journal › Article › peer-review